Journal of Cancer Research and Clinical Oncology

, Volume 132, Issue 11, pp 709–717

The prognostic significance of preoperative plasma levels of osteopontin in patients with hepatocellular carcinoma

  • Hui Zhang
  • Qing-Hai Ye
  • Ning Ren
  • Lei Zhao
  • Yan-Fang Wang
  • Xin Wu
  • Hui-Chuan Sun
  • Lu Wang
  • Bo-Heng Zhang
  • Yin-Kun Liu
  • Zhao-You Tang
  • Lun-Xiu Qin
Original Paper

DOI: 10.1007/s00432-006-0119-3

Cite this article as:
Zhang, H., Ye, QH., Ren, N. et al. J Cancer Res Clin Oncol (2006) 132: 709. doi:10.1007/s00432-006-0119-3

Abstract

We aimed to evaluate the prognostic value of preoperative plasma osteopontin (OPN) levels in 101 patients with hepatocellular carcinoma (HCC) who underwent liver resection. Plasma OPN levels were detected by ELISA. The association of plasma OPN levels of patients with clinicopathological characteristics, tumor recurrence, and survival was analyzed. The median plasma OPN level of patients was 176.90 ng/ml (range 13.73–780.00 ng/ml), which was significantly higher than that of 24 healthy volunteers (63.74 ng/ml, range 12.20–122.32 ng/ml). Plasma OPN levels were significantly different in patients with different numbers of tumor nodules (168.18 and 217.11 ng/ml for single and multiple nodules, respectively; P = 0.002), different Edmondson’s grades (201.24, 168.36, and 503.58 ng/ml for grades I, II, and III/IV, respectively; P = 0.015), and different TNM stages (168.16, 167.54, and 216.18 ng/ml for stages I, II, and III/IV, respectively; P = 0.016). Significantly higher plasma OPN levels were found in patients with a recurrence of HCC after resection, compared with those without recurrence (213.55 versus 153.70 ng/ml; P = 0.0013). A higher plasma OPN level was a leading independent prognostic factor for both overall survival (OS) and disease-free survival (DFS) in univariate and multivariate Cox models. This suggests that the preoperative plasma OPN level can be used as a predictive marker for HCC recurrence and may be helpful to assess the prognosis of patients with HCC after surgery.

Keywords

Hepatocellular carcinomaRecurrenceMetastasisPrognosisOsteopontin

Abbreviations

HCC

Hepatocellular carcinoma

OPN

Osteopontin

AFP

Alpha fetoprotein

IQR

Interquartile range

DFS

Disease-free survival

OS

Overall survival

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Hui Zhang
    • 1
  • Qing-Hai Ye
    • 1
  • Ning Ren
    • 1
  • Lei Zhao
    • 1
  • Yan-Fang Wang
    • 1
  • Xin Wu
    • 1
  • Hui-Chuan Sun
    • 1
  • Lu Wang
    • 1
  • Bo-Heng Zhang
    • 1
  • Yin-Kun Liu
    • 1
  • Zhao-You Tang
    • 1
  • Lun-Xiu Qin
    • 1
  1. 1.Liver Cancer Institute and Zhongshan HospitalInstitutes of Biomedical Science, Fudan UniversityShanghaiChina