Original Paper

Journal of Cancer Research and Clinical Oncology

, 132:521

First online:

Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients

  • Elaine Cristina MorariAffiliated withLaboratory of Cancer Molecular Genetics, Department of Medicine, Medical Sciences Faculty, State University of Campinas-UNICAMP
  • , Andre Bacellar Costa LimaAffiliated withLaboratory of Cancer Molecular Genetics, Department of Medicine, Medical Sciences Faculty, State University of Campinas-UNICAMP
  • , Natassia Elena BufaloAffiliated withLaboratory of Cancer Molecular Genetics, Department of Medicine, Medical Sciences Faculty, State University of Campinas-UNICAMP
  • , Janaina Luisa LeiteAffiliated withLaboratory of Cancer Molecular Genetics, Department of Medicine, Medical Sciences Faculty, State University of Campinas-UNICAMP
  • , Fabiana GranjaAffiliated withLaboratory of Cancer Molecular Genetics, Department of Medicine, Medical Sciences Faculty, State University of Campinas-UNICAMP
  • , Laura Sterian WardAffiliated withLaboratory of Cancer Molecular Genetics, Department of Medicine, Medical Sciences Faculty, State University of Campinas-UNICAMP Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Purpose . A series of polymorphisms in germ-line DNA have been investigated in an effort to delineate polygenic models of cancer susceptibility and prognosis. As low-penetrance susceptibility genes may combine additively or multiplicatively and contribute to cancer incidence and to the response to chemotherapy, we studied GSTT1, GSTM1, GSTO2, GSTP1 and codon 72 of p53 genotype profiles in ovarian cancer patients. Methods . We compared 69 ovarian cancer patients with 222 control healthy women paired for ethnic and life-style characteristics. Outcome was evaluated in 29 stage III and IV patients submitted to a platinum-based chemotherapy followed-up for 6–29 months (17 ± 9 months). Results . GSTT1, GSTM1, GSTO2 and GSTP1 genes presented a similar genotype distribution, but codon 72 of p53 gene wild-type variant was less frequent in ovarian cancer patients than in controls (χ2; = 0.0004). Conclusions. We were unable to demonstrate any association between the GST genotypes studied and the risk of ovarian cancer but the inheritance of a heterozygous Arg/Pro genotype of p53 increased the risk of ovarian cancer more than 2.5 times (OR = 2.571; 95% CI = 1.453–4.550). There was no association of the studied genes to any clinical or pathological feature of the patients or to their response to chemotherapy.

Keywords

Susceptibility Response to treatment Germline polymorphic inheritance