Journal of Cancer Research and Clinical Oncology

, Volume 131, Issue 4, pp 238–242

Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population

Authors

  • Yasuhiro Komiya
    • Department of Public HealthMiyazaki Medical College, University of Miyazaki
  • Hiromasa Tsukino
    • Department of Public HealthMiyazaki Medical College, University of Miyazaki
  • Hiroyuki Nakao
    • Department of Public HealthMiyazaki Medical College, University of Miyazaki
  • Yoshiki Kuroda
    • Department of Public HealthMiyazaki Medical College, University of Miyazaki
  • Hirohisa Imai
    • Department of Public HealthMiyazaki Medical College, University of Miyazaki
    • Department of Public HealthMiyazaki Medical College, University of Miyazaki
Original Paper

DOI: 10.1007/s00432-004-0634-z

Cite this article as:
Komiya, Y., Tsukino, H., Nakao, H. et al. J Cancer Res Clin Oncol (2005) 131: 238. doi:10.1007/s00432-004-0634-z

Abstract

Purpose: The incidence of prostate cancer is increasing in low-risk populations such as Japanese. One of the causes of this increase is considered to be associated with the Western diet, especially the high intake of red meat and fat. Glutathione S-transferase (GST) A1, T1, M1, and P1 are phase II enzymes that are important for activation and detoxification of chemical carcinogens.

Methods: In this study, 190 Japanese male patients with prostate cancer and 294 healthy controls, frequency-matched for age, were compared for frequencies of GSTA1, GSTT1, GSTM1, and GSTP1 genotypes.

Results: Among smokers, the frequency of the GSTA1*A/*B or *B/*B genotype in patients with prostate cancer (27.8%) showed a statistically significant increase compared with the control group frequency (18.2%; odds ratio [OR] =1.72; 95% CI, 1.01–2.94). In addition, the frequency of GSTT1 nondeletion genotype was associated with prostate cancer among smokers (OR =1.68; 95% CI, 1.06–2.68). The OR of carrying the combined genotyping of GSTA1*A/*B or *B/*B and GSTT1 nondeletion was 2.08 (95% CI, 1.14–3.80) with the combined genotyping of GSTA1*A/*A and GSTT1 null as a reference. On the other hand, no significant associations were observed for genotypes of GSTM1 and GSTP1 I105V.

Conclusions: These findings suggest that the GSTA1 and GSTT1 polymorphisms are associated with prostate cancer susceptibility, especially among smokers.

Keywords

GSTA1GSTT1PolymorphismProstate cancer

Copyright information

© Springer-Verlag 2004