Journal of Cancer Research and Clinical Oncology

, Volume 131, Issue 2, pp 73–79

Serum-soluble interleukin-2 receptor (sIL-2R) level determines clinical outcome in patients with aggressive non-Hodgkin’s lymphoma: in combination with the International Prognostic Index

Authors

  • Hideko Goto
    • First Department of Internal MedicineGifu University Graduate School of Medicine
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Hisashi Tsurumi
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Masao Takemura
    • Department of Clinical LaboratoryGifu University Graduate School of Medicine
  • Yoriko Ino-Shimomura
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Senji Kasahara
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Michio Sawada
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Toshiki Yamada
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Takeshi Hara
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Kenji Fukuno
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Naoe Goto
    • First Department of Internal MedicineGifu University Graduate School of Medicine
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Masataka Okuno
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Tsuyoshi Takami
    • Department of Cellular PathologyGifu University Graduate School of Medicine
  • Mitsuru Seishima
    • Department of Clinical LaboratoryGifu University Graduate School of Medicine
    • First Department of Internal MedicineGifu University Graduate School of Medicine
Original Paper

DOI: 10.1007/s00432-004-0600-9

Cite this article as:
Goto, H., Tsurumi, H., Takemura, M. et al. J Cancer Res Clin Oncol (2005) 131: 73. doi:10.1007/s00432-004-0600-9

Abstract

Purpose

The aim of the present study was to assess the prognostic significance of serum soluble interleukin-2 receptor (sIL-2R) in aggressive non-Hodgkin’s lymphoma (NHL).

Methods

One hundred and thirteen consecutive patients with previously untreated aggressive NHL (diffuse large B-cell lymphoma, 96; peripheral T-cell lymphoma, 17) prospectively participated in this study between 1995 and 2001. The patients were treated with 6–8 cycles of a CHOP or THP (pirarubicin)-COP regimen.

Results

A high serum sIL-2R level (2,000 U/ml and over) at onset was associated with a low complete remission rate. Patients with high sIL-2R had significantly lower survival rates (5-year, 24%) than those with low sIL-2R (under 2,000 U/ml) (74%) (P<0.01). Multivariate analysis employing sIL-2R levels and conventional prognostic factors demonstrated that high sIL-2R, presence of B-symptoms, and advanced age (60 years and older) were significantly unfavorable variables for overall survival. In addition, we attempted to use sIL-2R in combination with the International Prognostic Index (IPI). The patients in the high (H) risk group and those with high sIL-2R in the low-intermediate (LI)/high-intermediate (HI) risk group had significantly lower survival rates than the patients in the low (L) risk group and those with low sIL-2R in the LI/HI risk group (P<0.001).

Conclusion

The results suggest that a high serum sIL-2R level predicts a poor prognosis in aggressive NHL and may be a useful biomarker for selecting appropriate treatment when used in combination with the IPI.

Keywords

Soluble interleukin-2 receptor (sIL-2R)International Prognostic Index (IPI)Prognostic factorNon-Hodgkin’s lymphoma

Copyright information

© Springer-Verlag 2004