European Journal of Pediatrics

, Volume 160, Issue 6, pp 351–358

Human herpes virus type 7 DNA in the cerebrospinal fluid of children with central nervous system diseases

  • Annette Pohl-Koppe
  • Martin Blay
  • Gundula Jäger
  • Michael Weiss
ORIGINAL PAPER

DOI: 10.1007/s004310100732

Cite this article as:
Pohl-Koppe, A., Blay, M., Jäger, G. et al. Eur J Pediatr (2001) 160: 351. doi:10.1007/s004310100732

Abstract

Human herpes virus type 7 (HHV-7) has been associated with unspecific febrile syndrome, exanthem subitum (ES), viral rashes and Epstein-Barr virus (EBV) like syndrome. Neurological complications such as hemiplegia or seizures have been described in a few children with ES. Whether HHV-7 may also affect the CNS in the absence of ES is unknown. In this study, we investigated CSF samples from children with different neurological diseases for the presence of HHV-7 specific DNA. A HHV-7 specific nested polymerase chain reaction (PCR) was established amplifying a 478 bp DNA sequence of the glycoprotein U23 of HHV-7 strain SB. 68 children with CNS diseases with inflammatory CSF findings (n=24), CNS diseases without inflammatory CSF findings (n=18) and febrile seizures (n=26) were examined. A total of 26 children with infectious diseases in the absence of neurological disease and 11 children without signs of a peripheral infection and without neurological disease served as controls. The CSF samples of six children from the study groups were HHV-7 PCR positive, but none from the controls. These children were diagnosed with aseptic meningitis (n=1), viral encephalitis/meningoencephalitis (n=2), facial palsy (n=1), vestibular neuritis (n=1) and febrile seizure (n=1).

Conclusion These results indicate that human herpes virus type 7 infection is associated with central nervous system disease in children and should be considered in children whether inflammation in the cerebrospinal fluid is present or not.

Key words Central nervous systemChildrenHuman herpes virus type 7

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Annette Pohl-Koppe
    • 1
  • Martin Blay
    • 1
  • Gundula Jäger
    • 2
  • Michael Weiss
    • 1
  1. 1.Children's Hospital, Ludwig Maximilians University Munich, Lindwurmstrasse 4, 80337 Munich, Germany Tel.: +49-89-51603130; Fax: +49-89-51605388 e-mail: Annette.Pohl-Koppe@kk-i.med.uni-muenchen.deDE
  2. 2.Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, 80336 Munich, GermanyDE
  3. 3.Children's Hospital, 51058 Cologne, GermanyDE