CARDIOLOGY

European Journal of Pediatrics

, Volume 158, Issue 9, pp 698-701

First online:

Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

  • F. AspesberroAffiliated withCritical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75
  • , M. BeghettiAffiliated withCritical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75
  • , I. OberhänsliAffiliated withCritical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75
  • , H. ÖzsahinAffiliated withCritical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75
  • , J. HumbertAffiliated withCritical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75
  • , P. C. RimensbergerAffiliated withCritical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75

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Abstract

We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects.

Conclusion This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.

Key words Thrombolysis therapeutic Plasminogen activators Urokinase Thrombosis Infant Premature