, Volume 158, Issue 9, pp 698-701

Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

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We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects.

Conclusion This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.

Received: 4 November 1998 / Accepted in revised form: 5 February 1999