Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants
- Cite this article as:
- Aspesberro, F., Beghetti, M., Oberhänsli, I. et al. Eur J Pediatr (1999) 158: 698. doi:10.1007/s004310051182
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We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects.
Conclusion This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.