A patent ductus arteriosus is associated with reduced middle cerebral artery blood flow velocity
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The study objective was to determine the effect of a patent ductus arteriosus (PDA) on cerebral blood flow velocity in ventilated, very low birth weight neonates, in the first 5 days of life. Sonography of the right middle cerebral artery and ductus arteriosus was performed using a colour Doppler technique. Statistical analysis was by stepwise regression. Thirty-one neonates without and 43 with a PDA, mean (SD) birth weight 1004 g ± 192 and 1071 g ± 227 respectively, were studied. The end diastolic and mean velocities were reduced (P = 0.008 and P = 0.129) and the resistive index was increased (P = 0.047) by a PDA. pH was inversely related to end diastolic and mean velocities (P = 0.015 and P = 0.003), suggesting that low pH may increase cerebral artery blood flow velocity.
Conclusion A patent ductus arteriosus reduces middle cerebral artery blood flow velocity in very low birth weight neonates.
- A patent ductus arteriosus is associated with reduced middle cerebral artery blood flow velocity
European Journal of Pediatrics
Volume 158, Issue 6 , pp 484-487
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- Key words Cerebral blood flow velocity
- Ductus arteriosus
- Very low birth weight infant
- Colour Doppler
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- Author Affiliations
- A2. Department of Newborn and Developmental Paediatrics, Women's College Hospital, 76 Grenville Street, Toronto, Ontario M5S 1B2, Canada, e-mail address: email@example.com, Tel.: +1-416-323-6268, Fax: +1-416-323-6274, CA
- A1. Department of Medical Imaging, Women's College Hospital, Toronto, Ontario, Canada, CA