European Journal of Pediatrics

, Volume 158, Issue 5, pp 416–420

The clinical outcome after inferior vena cava thrombosis in early infancy

  • M. Häusler
  • D. Duque
  • U. Merz
  • R. Mertens
  • E. Mühler
  • H. Hörnchen
NEONATOLOGY

DOI: 10.1007/s004310051105

Cite this article as:
Häusler, M., Duque, D., Merz, U. et al. Eur J Pediatr (1999) 158: 416. doi:10.1007/s004310051105

Abstract

The clinical outcome after inferior vena cava thrombosis in early infancy is unknown. We report the clinical long-term follow-up of 12 patients presenting inferior vena cava thrombosis within their first months of life (gestational age: 24–41 weeks; follow-up: 7±3 years). Accompanying renal venous thrombosis occurred in 9, and adrenal bleeding in 4 patients. A central venous catheter was related to the thrombosis in only four patients. Heterozygous factor V Leiden mutation was found in two of the eight infants without central venous catheter. Thrombolysis was performed in seven and effective in three infants; one infant required surgical thrombectomy. In three of eight infants with ineffective or with no therapy, spontaneous recanalization occurred during follow-up. No patient died of the thrombosis. Although no long-term anticoagulatory prophylaxis was performed, none of the children with persisting occlusion (n=5) or stenosis (n=1) of the inferior vena cava developed symptomatic thrombo-embolic complications. However, extensive internal collaterals (n=6), visible varicosis (n=5), pain in the legs (n=3) and persisting renal disease (n=3) with arterial hypertension (n=2) were observed during follow-up.

Conclusion Inferior vena cava thrombosis of early infancy frequently persists and may cause considerable long-term morbidity. New strategies for early and long-term therapy are necessary.

Key words Factor V deficiency Infant Thrombosis Vena cava inferior 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • M. Häusler
    • 1
  • D. Duque
    • 2
  • U. Merz
    • 1
  • R. Mertens
    • 1
  • E. Mühler
    • 3
  • H. Hörnchen
    • 1
  1. 1.Department of Paediatrics, University Hospital RWTH Aachen, Pauwelsstr. 30, D-52057 Aachen, Germany, e-mail: Haeusler@RWTH-Aachen.de, Tel.: +49-241-8089738, Fax: +49-241-8888437DE
  2. 2.Department of Clinical Radiology, University Hospital RWTH Aachen, Aachen, GermanyDE
  3. 3.Department of Paediatric Cardiology, University Hospital RWTH Aachen, Aachen, GermanyDE

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