European Journal of Pediatrics

, Volume 156, Issue 9, pp 709–712

Acute disseminated demyelination due to primary human herpesvirus-6 infection

  • A. Kamei
  • S. Ichinohe
  • R. Onuma
  • S. Hiraga
  • T. Fujiwara
INFECTIOUS DISEASES

DOI: 10.1007/s004310050695

Cite this article as:
Kamei, A., Ichinohe, S., Onuma, R. et al. Eur J Pediatr (1997) 156: 709. doi:10.1007/s004310050695

Abstract

A previously healthy 19-month-old boy developed acute encephalopathy, thrombocytopenia and hepatic dysfunction. Human herpesvirus-6 (HHV-6) DNA was found in his CSF during the acute stage of the disease by means of the polymerase chain reaction. T2-weighted MRI revealed high signal intensity in the left thalamus and left parieto-occipital deep white matter. The myelin basic protein concentration in the CSF was elevated suggesting acute demyelination. The patient is now 2.5 years old and has no sequelae.

Conclusion Since clinical course and neuroimaging after HHV-6 infection are similar to those in acute disseminated encephalomyelitis, clinicians must pay attention to primary HHV-6 infection in patients under 2 years old with white matter lesions.

Key words Human herpesvirus-6Exanthem subitumEncephalopathyAcute demyelination

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Kamei
    • 1
  • S. Ichinohe
    • 1
  • R. Onuma
    • 1
  • S. Hiraga
    • 2
  • T. Fujiwara
    • 1
  1. 1.Department of Pediatrics, Iwate Medical University, Uchimaru 19-1, Morioka 020, Iwate, Japan, Tel.: 019-651-5111; Fax 019-651-0515.JP
  2. 2.Iwate Prefectural Kamaishi Hospital, Kamaishi, Iwate, JapanJP