European Journal of Pediatrics

, Volume 174, Issue 2, pp 209–215

Viral lower respiratory tract infections and preterm infants’ healthcare utilisation

  • Simon B. Drysdale
  • Mireia Alcazar-Paris
  • Theresa Wilson
  • Melvyn Smith
  • Mark Zuckerman
  • Janet L. Peacock
  • Sebastian L. Johnston
  • Anne Greenough
Original Article

DOI: 10.1007/s00431-014-2380-9

Cite this article as:
Drysdale, S.B., Alcazar-Paris, M., Wilson, T. et al. Eur J Pediatr (2015) 174: 209. doi:10.1007/s00431-014-2380-9

Abstract

The aim of this study was to determine whether respiratory syncytial virus (RSV) and other viral lower respiratory tract infections (LRTI) in prematurely born infants were associated with similar effects on healthcare utilisation and related cost of care in the second compared to the first year after birth. Thirteen infants who had RSV LRTIs (RSV), 21 who had other viral LRTIs (other viral) and 25 had no viral LRTIs (no LRTI) were prospectively followed. Nasopharyngeal aspirates were collected whenever an infant had an LRTI regardless of whether it was in the hospital or in the community. Healthcare utilisation and the health-related cost of care were determined. Only the RSV group compared to the no LRTI group had higher overall respiratory costs in both year 1 (mean, £3,917 versus £24; p < 0.041) and year 2 (mean, £1,164 versus £61; p = 0.012). Only the RSV group required respiratory admissions; the RSV admission rate in year 2 was 3.4 % (number needed to treat 59). Conclusion: RSV LRTIs are associated with increased healthcare utilisation and cost of care in the first and second year; nevertheless, if prophylaxis is to be cost-effective in the second year, a high risk group needs to be identified.

Keywords

Healthcare utilisationHealth-related cost of careLower respiratory tract infectionRespiratory syncytial virus

Abbreviations

BPD

Bronchopulmonary dysplasia

LRTI

Lower respiratory tract infection

NNT

Number needed to treat

NPA

Nasopharyngeal aspirate

PCR

Polymerase chain reaction

RSV

Respiratory syncytial virus

RV

Rhinovirus

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Simon B. Drysdale
    • 1
  • Mireia Alcazar-Paris
    • 1
  • Theresa Wilson
    • 1
  • Melvyn Smith
    • 2
  • Mark Zuckerman
    • 2
  • Janet L. Peacock
    • 3
    • 4
  • Sebastian L. Johnston
    • 5
  • Anne Greenough
    • 1
    • 3
    • 6
  1. 1.Division of Asthma, Allergy and Lung Biology, MRC-Asthma UK Centre in Allergic Mechanisms of AsthmaKing’s College LondonLondonUK
  2. 2.South London Specialist Virology CentreKing’s College HospitalLondonUK
  3. 3.NIHR Biomedical Research CentreGuy’s and St Thomas’ NHS Foundation Trust and King’s College LondonLondonUK
  4. 4.Division of Health and Social Care ResearchKing’s College LondonLondonUK
  5. 5.Airway Disease Infection Section, National Heart and Lung InstituteImperial College LondonLondonUK
  6. 6.Neonatal Intensive Care CentreKing’s College HospitalLondonUK