European Journal of Pediatrics

, Volume 173, Issue 7, pp 871–878

The burden of pneumococcal meningitis in Austrian children between 2001 and 2008

  • D. S. Klobassa
  • B. Zoehrer
  • M. Paulke-Korinek
  • U. Gruber-Sedlmayr
  • K. Pfurtscheller
  • V. Strenger
  • A. Sonnleitner
  • R. Kerbl
  • B. Ausserer
  • W. Arocker
  • W. Kaulfersch
  • B. Hausberger
  • B. Covi
  • F. Eitelberger
  • A. Vécsei
  • B. Simma
  • R. Birnbacher
  • H. Kurz
  • K. Zwiauer
  • D. Weghuber
  • S. Heuberger
  • F. Quehenberger
  • H. Kollaritsch
  • W. Zenz
Original Article

DOI: 10.1007/s00431-013-2260-8

Cite this article as:
Klobassa, D.S., Zoehrer, B., Paulke-Korinek, M. et al. Eur J Pediatr (2014) 173: 871. doi:10.1007/s00431-013-2260-8

Abstract

The present study was conducted to evaluate the burden of pneumococcal meningitis in Austrian children between 2001 and 2008. Clinical outcome was retrospectively analyzed both on discharge and on follow-up investigations. This study was based on a prospective multicentre surveillance study on hospitalized invasive pneumococcal infections in Austrian children with a total annual “study population” of about 399,000 children aged below 5 years per year. Between 2001 and 2008, 74 cases of pneumococcal meningitis were identified in children aged below 5 years. The mean annual incidence rate for pneumococcal meningitis was 2.3 per 100,000 children in this age group. In 57/74 children (mean age on admission 14.5 ± 13.3 months), outcome data on hospital discharge were available: 5 deaths (8.8 %), 20 children (35.1 %) with sequelae and 32 children (56.1 %) without sequelae were observed. Sequelae on discharge included motor impairment in 8 children (14.0 %), hearing impairment in 9 children (15.8 %) and/or other complications in 14 children (24.6 %). In 7/8 children with motor deficits, matching cerebral lesions were identified by neuroimaging: cerebral infarction in five children, cerebral vasculitis and cerebral abscess in one child each. In 40/57 children, long-term outcome (18.9 ± 20.2 months after discharge) could be assessed: 1 child (2.5 %) died 9 months after hospital discharge, 11 children (27.5 %) had one or two long-term sequelae and 28 children (70.0 %) had no sequelae. Long-term sequelae included motor impairment in three children (7.5 %), hearing impairment in nine children (22.5 %) and other deficits in two children (5.0 %). Conclusion: Our study confirms that pneumococcal meningitis causes high mortality and severe long-term sequelae. On long-term follow-up, we observed improvements of motor impairment, but not of hearing impairment.

Keywords

Bacterial meningitisStreptococcus pneumoniaePneumococcal diseaseChildrenLong-term outcomeLong-term sequelae

Supplementary material

431_2013_2260_MOESM1_ESM.pdf (15 kb)
Table 2Cerebral lesions with focal neurological deficits as complication of pneumococcal meningitis (PDF 14 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • D. S. Klobassa
    • 1
  • B. Zoehrer
    • 1
  • M. Paulke-Korinek
    • 2
  • U. Gruber-Sedlmayr
    • 1
  • K. Pfurtscheller
    • 3
  • V. Strenger
    • 1
  • A. Sonnleitner
    • 1
  • R. Kerbl
    • 4
  • B. Ausserer
    • 5
  • W. Arocker
    • 6
  • W. Kaulfersch
    • 7
  • B. Hausberger
    • 8
  • B. Covi
    • 9
  • F. Eitelberger
    • 10
  • A. Vécsei
    • 11
  • B. Simma
    • 12
  • R. Birnbacher
    • 13
  • H. Kurz
    • 14
  • K. Zwiauer
    • 15
  • D. Weghuber
    • 16
  • S. Heuberger
    • 17
  • F. Quehenberger
    • 18
  • H. Kollaritsch
    • 2
  • W. Zenz
    • 1
    • 19
  1. 1.Department of General Paediatrics, University Clinic of Paediatrics and Adolescent MedicineMedical University GrazGrazAustria
  2. 2.Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and ImmunologyMedical University ViennaViennaAustria
  3. 3.University Clinic of Paediatrics and Adolescent MedicineMedical University GrazGrazAustria
  4. 4.Department of Paediatrics and Adolescent MedicineGeneral Hospital of LeobenLeobenAustria
  5. 5.Department of Paediatrics and Adolescent MedicineGeneral Hospital of DornbirnDornbirnAustria
  6. 6.Department of Paediatrics and Adolescent MedicineRudolfstiftung Hospital ViennaViennaAustria
  7. 7.Department of Paediatrics and Adolescent MedicineGeneral Hospital of KlagenfurtKlagenfurtAustria
  8. 8.Department of Paediatrics and Adolescent MedicineGeneral Hospital of Wiener NeustadtWiener NeustadtAustria
  9. 9.Department of Paediatrics and Adolescent MedicineMedical University InnsbruckInnsbruckAustria
  10. 10.Department of PaediatricsKlinikum Wels GrieskirchenWelsAustria
  11. 11.St. Anna Children’s Hospital, Department of PaediatricsMedical University ViennaViennaAustria
  12. 12.Department of PaediatricsAcademic Teaching Hospital FeldkirchFeldkirchAustria
  13. 13.Department of Paediatrics and Adolescent MedicineGeneral Hospital of VillachVillachAustria
  14. 14.Department of Paediatrics and Adolescent MedicineDanube HospitalViennaAustria
  15. 15.Department of Paediatric and Adolescent MedicineClinicum St. PöltenSt. PöltenAustria
  16. 16.Department of Paediatrics, Salzburger LandesklinikenParacelsus Medical UniversitySalzburgAustria
  17. 17.Austrian Agency for Health and Food SafetyGrazAustria
  18. 18.Institute of Medical Informatics, Statistics and DocumentationMedical University GrazGrazAustria
  19. 19.Research Unit Infectiology and Vaccinology, Department of General PaediatricsMedical University GrazGrazAustria