European Journal of Pediatrics

, Volume 173, Issue 4, pp 497–502

Symptom positivity is essential for omitting biopsy in children with suspected celiac disease according to the new ESPGHAN guidelines

  • Jiri Nevoral
  • Radana Kotalova
  • Ondrej Hradsky
  • Vera Valtrova
  • Kristyna Zarubova
  • Jan Lastovicka
  • Eva Neubertova
  • Marketa Trnkova
  • Jiri Bronsky
Original Article

DOI: 10.1007/s00431-013-2215-0

Cite this article as:
Nevoral, J., Kotalova, R., Hradsky, O. et al. Eur J Pediatr (2014) 173: 497. doi:10.1007/s00431-013-2215-0

Abstract

The aim of this study was to assess the accuracy of serological tests in combination with clinical symptoms for diagnosing celiac disease (CD) according to the new proposed European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) criteria. We retrospectively assessed children and adolescents aged 16 months –19 years who were examined for suspicion of CD (n = 345). Evaluation of clinical symptoms and the presence of tissue transglutaminase (anti-TG-IgA) and endomysial antibodies (EMA-IgA) as well as intestinal biopsies was performed in all patients. Human leukocyte antigens (HLAs) were not included. Among 345 biopsied children, 213 (62 %) children had anti-TG titers >10 times the upper limit of normal (ULN) and positive EMA antibodies. Ninety-nine (29 %) children also had symptoms suggestive of CD in addition to EMA positivity and elevated titers of anti-TG >10 times the ULN. In patients who were asymptomatic, but positive for EMA, and had anti-TG antibodies >10 times the ULN, the specificity of tests for Marsh 2–3 was only 85 %, while in symptomatic patients with the same antibodies levels, the specificity was 99 %. Conclusion: Our results reveal that intestinal biopsies could be omitted in 28 % of patients when the new ESPGHAN guidelines are applied. Due to high accuracy of serological tests in combination with clinical symptoms for diagnosis of CD, the new guideline seems to be applicable even without the use of HLA testing.

Keywords

Celiac disease Guidelines Diagnosis Children 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Jiri Nevoral
    • 1
  • Radana Kotalova
    • 1
  • Ondrej Hradsky
    • 1
  • Vera Valtrova
    • 1
  • Kristyna Zarubova
    • 1
  • Jan Lastovicka
    • 2
  • Eva Neubertova
    • 3
  • Marketa Trnkova
    • 3
  • Jiri Bronsky
    • 1
  1. 1.Department of Pediatrics, University Hospital Motol, 2nd Medical SchoolCharles UniversityPrague 5Czech Republic
  2. 2.Institute of Immunology, University Hospital Motol, 2nd Medical SchoolCharles UniversityPragueCzech Republic
  3. 3.BIOLAB Praha, s.r.oPrague 6Czech Republic

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