European Journal of Pediatrics

, Volume 173, Issue 4, pp 469–476

Characteristics of invasive pneumococcal disease in hospitalized children in Austria

  • Maria Paulke-Korinek
  • Herwig Kollaritsch
  • Michael Kundi
  • Birgit Schmidle-Loss
  • Ines Zwazl
  • Brigitte Laaber
  • Karin Lakovits
  • Andreas Vecsei
  • Ursula Wiedermann
  • Heinz Burgmann
Original Article

DOI: 10.1007/s00431-013-2193-2

Cite this article as:
Paulke-Korinek, M., Kollaritsch, H., Kundi, M. et al. Eur J Pediatr (2014) 173: 469. doi:10.1007/s00431-013-2193-2

Abstract

In a prospective surveillance study covering all pediatric wards in Austria, 308 cases of invasive pneumococcal disease (IPD) were reported in hospitalized children <5 years of age between 2002 and 2012. Incidence was 7.1 per 100,000 per year for IPD with a case fatality rate of 3 %, and 1.9 per 100,000 per year for pneumococcal meningitis with a case fatality rate of 9 %. At hospital discharge, 17 % of the children were not fully recovered and suffered from problems such as hearing or motor deficits. Persistent sequelae 6 months after hospital discharge were present in 13 % of the children, a finding that emphasizes the seriousness of IPD. From 2007 onwards, we observed a shift of pneumococcal serotypes from those covered by the heptavalent vaccine to serotypes consequently added to 10- and 13-valent vaccines, particularly regarding serotype 19A. Among antimicrobial resistances detected, macrolide resistance was predominant; however, between 2002 and 2012, we saw an overall decrease of resistance rates. Conclusion: Considering this change of serotypes and the high rate of permanent sequelae after IPD, our data show the importance of pediatric pneumococcal vaccination and the relevance of continuous monitoring of circulating serotypes. By the end of 2012, which was the first year of universal mass vaccination against pneumococcal disease in Austria, no change in the incidence of invasive pneumococcal disease was observed yet.

Keywords

Streptococcus pneumoniaeInvasive pneumococcal diseaseSerotypesAntimicrobial resistance

Abbreviations

IPD

Invasive pneumococcal disease

PCV7

Heptavalent conjugated pneumococcal vaccines

PCV10

Ten-valent conjugated pneumococcal vaccine

PCV13

Thirteen-valent conjugated pneumococcal vaccine

MIC

Minimal inhibitory concentrations

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Maria Paulke-Korinek
    • 1
  • Herwig Kollaritsch
    • 1
  • Michael Kundi
    • 2
  • Birgit Schmidle-Loss
    • 1
  • Ines Zwazl
    • 1
  • Brigitte Laaber
    • 1
  • Karin Lakovits
    • 3
  • Andreas Vecsei
    • 4
  • Ursula Wiedermann
    • 1
  • Heinz Burgmann
    • 3
  1. 1.Institute of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and ImmunologyMedical University ViennaViennaAustria
  2. 2.Institute of Environmental Health, Center for Public HealthMedical University ViennaViennaAustria
  3. 3.Division of Infectious Diseases and Tropical Medicine, Department of Medicine IMedical University ViennaViennaAustria
  4. 4.St. Anna Children’s Hospital, Department of Pediatric and Adolescent MedicineMedical University ViennaViennaAustria