European Journal of Pediatrics

, Volume 172, Issue 11, pp 1527–1533

Randomized controlled trial of topical EMLA and breastfeeding for reducing pain during wDPT vaccination

  • Navratan Kumar Gupta
  • Amit Upadhyay
  • Astha Agarwal
  • Gaurav Goswami
  • Jagdish Kumar
  • V. Sreenivas
Original Article

DOI: 10.1007/s00431-013-2076-6

Cite this article as:
Gupta, N.K., Upadhyay, A., Agarwal, A. et al. Eur J Pediatr (2013) 172: 1527. doi:10.1007/s00431-013-2076-6

Abstract

The primary objective was to evaluate the analgesic effect of a eutectic mixture of local anesthetics (EMLA) during whole cell DPT vaccination. The secondary objective was to evaluate if the analgesic effect of EMLA was synergistic to breastfeeding. A randomized, placebo-controlled trial was done to include infants of up to 3 months of age who came for their first DPT vaccination. The outcome variables were duration of cry, latency of onset of cry, and Modified Facial Coding Score. Thirty babies were enrolled in each of three groups. The groups did not differ significantly in baseline characteristics. Median (interquartile range) of duration of cry was least [34.6 (24.1–72.2) s] in babies receiving EMLA cream with breastfeeding (EB group), followed by 94.2 (46.1–180) s in babies receiving EMLA cream with oral distilled water (EW group), as compared to 180.0 (180–180) s in babies receiving placebo cream with oral distilled water (PCW group) (p < 0.05). Mean (SD) of latency of cry was significantly greater in EB group [2.4 (1.14) s] and EW group [1.9 (0.62) s] as compared to babies in PCW group [1.5 (0.47) s] (p < 0.05), but the difference between EB and EW groups was not significant. Modified Facial Coding Score was significantly lower in EB group as compared to the other groups (p < 0.05). Conclusions: Topical EMLA is effective in reducing pain and has a synergistic effect in analgesia when combined with breastfeeding during vaccination in infants.

Keywords

Duration of cry DPT vaccination EMLA Pain Infant 

Abbreviations

ANOVA

Analysis of variance

SD

Standard deviation

IQR

Interquartile range

MFCS

Modified Facial Coding Score

wDPT

Whole cell DPT vaccine

EMLA

Eutectic mixture of local anesthetics

EB group

Babies receiving EMLA cream with breastfeeding

EW group

Babies receiving EMLA cream with oral distilled water

PCW group

Babies receiving placebo cream with oral distilled water

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Navratan Kumar Gupta
    • 1
  • Amit Upadhyay
    • 1
  • Astha Agarwal
    • 1
  • Gaurav Goswami
    • 1
  • Jagdish Kumar
    • 1
  • V. Sreenivas
    • 2
  1. 1.Department of PediatricsLLRM Medical CollegeMeerutIndia
  2. 2.Department of BiostatisticsAll India Institute of Medical SciencesNew DelhiIndia

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