Autoimmune chronic urticaria: transferability of autologous serum skin test
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- Pastore, S., Berti, I. & Longo, G. Eur J Pediatr (2013) 172: 569. doi:10.1007/s00431-013-1936-4
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At least 30 % of children with chronic urticaria have an autoimmune aetiology with a positive autologous serum skin test (ASST). ASST is cheap, easy to perform and has good sensibility and specificity in detecting autoantibodies. In case of concern about reliability of ASST because of antihistamine medications, test transferability seems to be feasible.
KeywordsChronic urticariaAutoimmune urticariaASSTAntihistamine
A 13-year-old female presented with a 4-month history of worsening urticaria frequently associated with angioedema and hardly controlled by high doses of antihistamine (10 mg daily). Urticaria did not seem to be triggered by physical stimuli.
Overall, 0.1–3 % of children are diagnosed with chronic urticaria (CU) . In nearly 30 % of patients with CU, active autoantibodies against IgE or its receptor have been identified [2, 3]. The autologous serum skin test is an in vivo clinical test which has been suggested as a screening tool for CAU [2, 3]. Interestingly, despite full antihistamine therapy, the patient test resulted positive, although much less pronounced. This incomplete test inhibition by antihistamine therapy has already been reported in the literature .
Conflict of interest
None to declare.