European Journal of Pediatrics

, Volume 172, Issue 4, pp 563–567

Drug-resistant tuberculosis in two children in Greece: Report of the first extensively drug-resistant case

  • Aspasia Katragkou
  • Charalampos Antachopoulos
  • Elpis Hatziagorou
  • Maria Sdougka
  • Emmanuel Roilides
  • John Tsanakas
Case Report

DOI: 10.1007/s00431-012-1811-8

Cite this article as:
Katragkou, A., Antachopoulos, C., Hatziagorou, E. et al. Eur J Pediatr (2013) 172: 563. doi:10.1007/s00431-012-1811-8

Abstract

Extensively drug-resistant (XDR) tuberculosis (TB) represents a serious and growing problem in both endemic and non-endemic countries. We describe a 2.5-year-old girl with XDR-pulmonary TB and an 18-month-old boy with pre-XDR-central nervous system TB. Patients received individualized treatment with second-line anti-TB agents based on genotypic and phenotypic drug susceptibility testing results. Both children achieved culture conversion 3 months and 1 month after treatment initiation, respectively. The child with XDR-pulmonary TB showed evidence of cure while treatment adverse events were managed without treatment interruption. The child with pre-XDR-central nervous system TB after 6-month hospitalization with multiple infectious complications had a dismal end due to hepatic insufficiency possibly related to anti-TB treatment. This is the first report of children with pre-XDR and XDR TB in Greece, emphasizing the public health dimensions and management complexity of XDR TB.

Keywords

TuberculosisChildrenExtensively drug-resistantMultidrug-resistantPneumoniaCentral nervous system

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Aspasia Katragkou
    • 1
  • Charalampos Antachopoulos
    • 1
  • Elpis Hatziagorou
    • 1
  • Maria Sdougka
    • 2
  • Emmanuel Roilides
    • 1
    • 3
  • John Tsanakas
    • 1
  1. 1.3rd Department of Pediatrics, School of MedicineAristotle UniversityThessalonikiGreece
  2. 2.Pediatric Intensive Care UnitHippokration HospitalThessalonikiGreece
  3. 3.3rd Department of PediatricsHippokration HospitalThessalonikiGreece