European Journal of Pediatrics

, Volume 171, Issue 8, pp 1167–1173

Maternal mumps antibodies in a cohort of children up to the age of 1 year

  • E. Leuridan
  • N. Goeyvaerts
  • N. Hens
  • V. Hutse
  • P. Van Damme
Original Article

DOI: 10.1007/s00431-012-1691-y

Cite this article as:
Leuridan, E., Goeyvaerts, N., Hens, N. et al. Eur J Pediatr (2012) 171: 1167. doi:10.1007/s00431-012-1691-y

Abstract

The duration of the presence of maternal mumps antibodies in a prospective cohort study is presented. Immunoglobulin G against mumps was portioned with a commercial ELISA test (Euroimmun® anti-mumps Virus AT ELISA, Germany) on samples from 213 mother–child pairs at seven time points between pregnancy and 12 months of age. Non-linear mixed models were used to model maternal antibody decay in infants. The model-based median time to loss of antibodies was 3.6 months. The median child-specific time to loss of antibodies in children of naturally immune women (3.8 months) and children of vaccinated women (2.4 months) differed significantly (p = 0.025). The log antibody level of the mother and the log birth weight were correlated with the duration of maternal antibodies in infants (p < 0.0001). Conclusion: Children of vaccinated women loose maternal mumps antibodies significantly earlier in life compared to children of naturally infected women. If early administration (<12 months) of the combined measles, mumps, and rubella vaccine is needed, maternal mumps antibodies are not expected to interfere with infant humoral vaccine responses.

Keywords

MumpsMaternal antibodiesVaccination

Supplementary material

431_2012_1691_MOESM1_ESM.pdf (33 kb)
ESM 1(PDF 32.6 kb)

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • E. Leuridan
    • 1
  • N. Goeyvaerts
    • 2
    • 3
  • N. Hens
    • 2
    • 3
  • V. Hutse
    • 4
  • P. Van Damme
    • 1
  1. 1.Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, WHO Collaborating Centre for Control and Prevention of Infectious DiseasesUniversity of AntwerpWilrijkBelgium
  2. 2.Interuniversity Institute for Biostatistics and statistical BioinformaticsHasselt UniversityHasseltBelgium
  3. 3.Centre for Health Economics Research and Modelling Infectious Diseases, Vaccine and Infectious Disease Institute, WHO Collaborating Centre for Control and Prevention of Infectious DiseasesUniversity of AntwerpAntwerpBelgium
  4. 4.National Reference Center for Measles and Rubella, OD Communicable and Infectious Diseases–Viral DiseasesScientific Institute of Public HealthBrusselsBelgium