European Journal of Pediatrics

, Volume 171, Issue 3, pp 485–492

Health-related quality of life of pediatric patients with moderate to severe plaque psoriasis: comparisons to four common chronic diseases

  • James W. Varni
  • Denise R. Globe
  • Shravanthi R. Gandra
  • David J. Harrison
  • Michele Hooper
  • Scott Baumgartner
Original Paper

DOI: 10.1007/s00431-011-1587-2

Cite this article as:
Varni, J.W., Globe, D.R., Gandra, S.R. et al. Eur J Pediatr (2012) 171: 485. doi:10.1007/s00431-011-1587-2

Abstract

Health-related quality of life (HRQOL) is an important indicator of the burden of illness in moderate-to-severe plaque psoriasis. This study evaluated self-reported generic HRQOL among pediatric patients with moderate-to-severe plaque psoriasis based on pooled baseline clinical trial data and compared them to four common chronic diseases and to a healthy sample. The Pediatric Quality of Life Inventory Version 4.0 (PedsQL™ 4.0) Generic Core Scales was administered to 208 patients ages 4 to 17 years with stable, moderate-to-severe plaque psoriasis. Patients with moderate-to-severe plaque psoriasis were compared using one-sample t-tests to published PedsQL™ (http://www.pedsql.org) data on healthy children and pediatric patients with arthritis, psychiatric disorders, asthma, and diabetes. Pediatric patients with moderate-to-severe plaque psoriasis demonstrated significantly impaired physical, emotional, social, and school functioning in comparison to healthy children. The PedsQL™ Emotional and School Functioning Scales demonstrated the largest mean difference between the two groups (12.1, 11.1 points, respectively). In general, patients with plaque psoriasis demonstrated significantly more impaired generic HRQOL compared to patients with diabetes, comparable HRQOL to arthritis and asthma, and better HRQOL than psychiatric patients. In conclusion, the findings indicate that pediatric patients with moderate-to-severe plaque psoriasis have significantly impaired generic HRQOL in comparison to healthy children, and HRQOL generally comparable to other serious chronic diseases. These results demonstrate the significant negative impact of plaque psoriasis on the daily lives of these children from the patients’ perspective.

Keywords

Plaque psoriasisPediatricsPedsQLHealth-related quality of lifePatient-reported outcomes

Abbreviations

PedsQL™

Pediatric Quality of Life Inventory™

FDA

Food and Drug Administration

HRQOL

Health-related quality of life

NS

Nonsignificant

BSA

Body-surface area

PASI

Psoriasis area-and-severity index

CI

Confidence interval

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • James W. Varni
    • 1
    • 2
  • Denise R. Globe
    • 3
  • Shravanthi R. Gandra
    • 3
  • David J. Harrison
    • 3
  • Michele Hooper
    • 3
  • Scott Baumgartner
    • 3
  1. 1.Department of Pediatrics, College of MedicineTexas A&M UniversityCollege StationUSA
  2. 2.Department of Landscape Architecture and Urban Planning, Center for Health Systems + Design, College of ArchitectureTexas A&M UniversityCollege StationUSA
  3. 3.AmgenThousand OaksUSA