Original Paper

European Journal of Pediatrics

, Volume 169, Issue 4, pp 457-461

First online:

Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease

  • Sung Wook ParkAffiliated withDepartment of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University
  • , Ju Yeon BanAffiliated withDepartment of Pharmacology, College of Dentistry, Dankook University
  • , Kyung Lim YoonAffiliated withDepartment of Pediatrics, East–West Neo Medical Center, Kyung Hee University
  • , Hak Jae KimAffiliated withKohwang Medical Research Institute, School of Medicine, Kyung Hee University
  • , Jun Young ChungAffiliated withDepartment of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University
  • , Jae Woo YiAffiliated withDepartment of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University
  • , Bong Jae LeeAffiliated withDepartment of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University
  • , Joo-Ho ChungAffiliated withKohwang Medical Research Institute, School of Medicine, Kyung Hee University Email author 

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Abstract

Kawasaki disease (KD) is an acute vasculitis of childhood that predominantly affects the coronary arteries. We investigated single nucleotide polymorphisms (SNPs) of the tryptophan hydroxylase 2 (TPH2) gene as risk factors for KD with coronary artery lesions (CALs) in Korean children. We genotyped two SNPs [rs7305115 (exon 7) and rs4290270 (exon 9)] using direct sequencing in 101 KD and 256 control subjects. To analyze the genetic data, SNPStats, SNPAnalyzer, and Helixtree programs were used. The genotype analysis of rs7305115 and rs4290270 showed no significant differences between KD and control groups. However, we found a statistically significant association between the two SNPs and the development of CALs in KD (p < 0.05). The minor homozygous genotype (rs7305115, AA genotype and rs42901270, AA genotype) of each SNP showed increased susceptibility to risk of CALs in KD patients. These results suggest that TPH2 may be associated with the development of KD with CALs in Korean children.

Keywords

Coronary artery lesion Kawasaki disease Single nucleotide polymorphism Tryptophan hydroxylase 2