European Journal of Pediatrics

, Volume 169, Issue 4, pp 457–461

Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease

  • Sung Wook Park
  • Ju Yeon Ban
  • Kyung Lim Yoon
  • Hak Jae Kim
  • Jun Young Chung
  • Jae Woo Yi
  • Bong Jae Lee
  • Joo-Ho Chung
Original Paper

DOI: 10.1007/s00431-009-1056-3

Cite this article as:
Park, S.W., Ban, J.Y., Yoon, K.L. et al. Eur J Pediatr (2010) 169: 457. doi:10.1007/s00431-009-1056-3

Abstract

Kawasaki disease (KD) is an acute vasculitis of childhood that predominantly affects the coronary arteries. We investigated single nucleotide polymorphisms (SNPs) of the tryptophan hydroxylase 2 (TPH2) gene as risk factors for KD with coronary artery lesions (CALs) in Korean children. We genotyped two SNPs [rs7305115 (exon 7) and rs4290270 (exon 9)] using direct sequencing in 101 KD and 256 control subjects. To analyze the genetic data, SNPStats, SNPAnalyzer, and Helixtree programs were used. The genotype analysis of rs7305115 and rs4290270 showed no significant differences between KD and control groups. However, we found a statistically significant association between the two SNPs and the development of CALs in KD (p < 0.05). The minor homozygous genotype (rs7305115, AA genotype and rs42901270, AA genotype) of each SNP showed increased susceptibility to risk of CALs in KD patients. These results suggest that TPH2 may be associated with the development of KD with CALs in Korean children.

Keywords

Coronary artery lesionKawasaki diseaseSingle nucleotide polymorphismTryptophan hydroxylase 2

Abbreviations

TPH2

Tryptophan hydroxylase 2

KD

Kawasaki disease

CALs

Coronary artery lesions

SNP

Single nucleotide polymorphism

IVIG

Intravenous immunoglobulin

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Sung Wook Park
    • 1
  • Ju Yeon Ban
    • 2
  • Kyung Lim Yoon
    • 4
  • Hak Jae Kim
    • 3
  • Jun Young Chung
    • 1
  • Jae Woo Yi
    • 1
  • Bong Jae Lee
    • 1
  • Joo-Ho Chung
    • 3
  1. 1.Department of Anesthesiology and Pain Medicine, School of MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of Pharmacology, College of DentistryDankook UniversityChungnamRepublic of Korea
  3. 3.Kohwang Medical Research Institute, School of MedicineKyung Hee UniversitySeoulRepublic of Korea
  4. 4.Department of Pediatrics, East–West Neo Medical CenterKyung Hee UniversitySeoulRepublic of Korea