European Journal of Pediatrics

, Volume 169, Issue 2, pp 149–164

Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children

  • Jan Philipp Schuchardt
  • Michael Huss
  • Manuela Stauss-Grabo
  • Andreas Hahn
Review

DOI: 10.1007/s00431-009-1035-8

Cite this article as:
Schuchardt, J.P., Huss, M., Stauss-Grabo, M. et al. Eur J Pediatr (2010) 169: 149. doi:10.1007/s00431-009-1035-8

Abstract

ω-6 and ω-3 polyunsaturated fatty acids (PUFAs) play a central role in the normal development and functioning of the brain and central nervous system. Long-chain PUFAs (LC-PUFAs) such as eicosapentaenoic acid (EPA, C20:5ω-3), docosahexaenoic acid (DHA, C22:6ω-3) and arachidonic acid (AA, C20:4ω-6), in particular, are involved in numerous neuronal processes, ranging from effects on membrane fluidity to gene expression regulation. Deficiencies and imbalances of these nutrients, not only during the developmental phase but throughout the whole life span, have significant effects on brain function. Numerous observational studies have shown a link between childhood developmental disorders and ω-6:ω-3 fatty acid imbalances. For instance, neurocognitive disorders such as attention-deficit hyperactivity disorder (ADHD), dyslexia, dyspraxia and autism spectrum disorders are often associated with a relative lack of ω-3 fatty acids. In addition to a high ω-6 fatty acid intake and, in many cases, an insufficient supply of ω-3 fatty acids among the population, evidence is increasing to suggest that PUFA metabolism can be impaired in individuals with ADHD. In this context, PUFA imbalances are being discussed as potential risk factors for neurodevelopmental disorders. Another focus is whether the nutritive PUFA requirements—especially long-chain ω-3 fatty acid requirements—are higher among some individuals. Meanwhile, several controlled studies investigated the clinical benefits of LC-PUFA supplementation in affected children and adolescents, with occasionally conflicting results.

Keywords

Omega-3 fatty acidsEPADHAFatty acid metabolismChildhood developmental disordersAttention-deficit hyperactivity disorder (ADHD)

Abbreviations

ABC

Aberrant Behaviour Checklist

COX

Cyclooxygenase

DSM-IV

Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition

CBCL

Child Behaviour Checklist

CDI

Children’s Depression Inventory

CDRS

Children’s Depression Rating Scale

CGI

Clinical Global Impression

CTRSL

Conners’ Teacher Rating Scales, Long Version

FADS

Fatty acid desaturase

LOX

Lipoxygenase

PL

Phospholipase A2

PUFAs

Polyunsaturated fatty acids

IVA/CPT

Intermediate Visual and Auditory/Continuous Performance Test

LC-PUFAs

Long-chain polyunsaturated fatty acids

TOVA

Test of Variables of Attention

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jan Philipp Schuchardt
    • 1
  • Michael Huss
    • 2
  • Manuela Stauss-Grabo
    • 3
  • Andreas Hahn
    • 1
  1. 1.Institute of Food Science, Nutrition physiology and human nutrition unitLeibniz University of HanoverHanoverGermany
  2. 2.Department for Child and Adolescent PsychiatryJohannes Gutenberg-UniversityMainzGermany
  3. 3.Engelhard Arzneimittel GmbH & Co.KGNiederdorfeldenGermany