European Journal of Pediatrics

, 169:35

Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome

Authors

    • Department of Pediatrics BSchneider Children’s Medical Center of Israel
    • Kipper Institute of Allergy and ImmunologySchneider Children’s Medical Center of Israel
    • Sackler Faculty of MedicineTel Aviv University
  • Adit Ben-Baruch
    • Department of Cell Research and ImmunologyTel Aviv University
  • Asaf Rolinsky
    • Department of Pediatrics BSchneider Children’s Medical Center of Israel
    • Kipper Institute of Allergy and ImmunologySchneider Children’s Medical Center of Israel
    • Sackler Faculty of MedicineTel Aviv University
  • Cristina Woellner
    • Department of Immunology and Molecular Pathology, Royal Free HospitalUniversity College
  • Bodo Grimbacher
    • Department of Immunology and Molecular Pathology, Royal Free HospitalUniversity College
  • Nufar Marcus
    • Department of Pediatrics BSchneider Children’s Medical Center of Israel
    • Kipper Institute of Allergy and ImmunologySchneider Children’s Medical Center of Israel
    • Sackler Faculty of MedicineTel Aviv University
Original Paper

DOI: 10.1007/s00431-009-0973-5

Cite this article as:
Garty, B.Z., Ben-Baruch, A., Rolinsky, A. et al. Eur J Pediatr (2010) 169: 35. doi:10.1007/s00431-009-0973-5

Abstract

A 4-month-old baby with a family history of hyper-IgE syndrome acquired Pneumocystis jirovecii pneumonia. The patient’s hyper-IgE syndrome score was low, but a genetic study yielded a STAT3 mutation. P. jirovecii pneumonia can be added to the infections associated with hyper-IgE syndrome. In some cases, it may be the presenting manifestation of this immunodeficiency.

Keywords

Hyper-IgE syndromePneumocystis jiroveciiImmunodeficiencySTAT3 mutation

Abbreviations

HIES

Hyper-IgE syndrome

PCR

Polymerase chain reaction

P

Pneumocystis

NK

Natural killer

Copyright information

© Springer-Verlag 2009