Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome
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- Garty, B.Z., Ben-Baruch, A., Rolinsky, A. et al. Eur J Pediatr (2010) 169: 35. doi:10.1007/s00431-009-0973-5
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A 4-month-old baby with a family history of hyper-IgE syndrome acquired Pneumocystis jirovecii pneumonia. The patient’s hyper-IgE syndrome score was low, but a genetic study yielded a STAT3 mutation. P. jirovecii pneumonia can be added to the infections associated with hyper-IgE syndrome. In some cases, it may be the presenting manifestation of this immunodeficiency.
KeywordsHyper-IgE syndromePneumocystis jiroveciiImmunodeficiencySTAT3 mutation
Polymerase chain reaction