‘Poppy seeds’ in stomach aspirates: is oral omeprazole extemporaneous dispersion bioavailable?
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We report the appearance of ‘poppy seed’-like structures found in the aspirated stomach contents and faeces of a 3-month-old infant receiving an omeprazole liquid via nasogastric tube, prepared by dispersing an omeprazole tablet (10 mg MUPS®) in water. Electron microscopy and mass spectroscopy indicated that these particles were hollow, dark purple coloured spheres comprising undissolved omeprazole and its degradation products. These observations suggest rapid degradation of omeprazole in the acid stomach contents, with compromised absorption of active drug. Consequently, dispersion of omeprazole in water may be an inappropriate formulation in this setting.
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European Journal of Pediatrics
Volume 167, Issue 7 , pp 823-825
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Liquid omeprazole
- Paediatric administration
- Extemporaneous disperson in water
- Industry Sectors
- Author Affiliations
- 1. Department of Pharmaceutics, The School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK
- 2. Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK
- 6. The School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK
- 3. Pharmacy Department, Evelina Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
- 4. Electron Microscopy Unit, The School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK
- 5. Paediatric Intensive Care Unit, Evelina Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK