European Journal of Pediatrics

, Volume 167, Issue 1, pp 75–80

Clinical manifestations of human coronavirus NL63 infection in children in Taiwan

  • Ping-Sheng Wu
  • Luan-Yin Chang
  • B. Berkhout
  • L. van der Hoek
  • Chun-Yi Lu
  • Chuan-Liang Kao
  • Ping-Ing Lee
  • Pei-Lan Shao
  • Chin-Yun Lee
  • Fu-Yuan Huang
  • Li-Min Huang
Original Paper

DOI: 10.1007/s00431-007-0429-8

Cite this article as:
Wu, P., Chang, L., Berkhout, B. et al. Eur J Pediatr (2008) 167: 75. doi:10.1007/s00431-007-0429-8

Abstract

Human coronavirus NL63 (HCoV-NL63) is a global respiratory tract pathogen; however, the epidemiology of this virus in subtropical area is not well known. To evaluate the epidemics and disease spectrum of HCoV-NL63 infection in children in Taiwan, we prospectively screened children admitted to the hospital with respiratory tract infection from May 2004 to April 2005. Every enrolled child had a nasopharyngeal aspirate (NPA) sample taken. Quantitative RT-PCR was used to detect 1b gene of HCoV-NL63. A total of 539 NPAs were collected. Seven (1.3%) were positive for HCoV-NL63. All cases were boys younger than 3 years of age and most cases occurred in autumn. Co-infection with other pathogens was observed in three cases. The most common symptoms/signs of HCoV-NL63 infection were cough, fever, and inspiratory stridor. HCoV-NL63 was the most common pathogen (14.7%) in children with croup and was the cause of three cases of croup in October. The odds ratio of croup in children infected with HCoV-NL63 was 43.4 (95% CI 8.1∼233.1). In conclusion, HCoV-NL63 is an important respiratory tract pathogen as the main cause in children admitted to the hospital in Taiwan.

Keywords

Coronavirus infectionsRespiratory tract infectionsCroupTaiwan

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ping-Sheng Wu
    • 1
  • Luan-Yin Chang
    • 2
  • B. Berkhout
    • 5
  • L. van der Hoek
    • 5
  • Chun-Yi Lu
    • 2
  • Chuan-Liang Kao
    • 3
  • Ping-Ing Lee
    • 2
  • Pei-Lan Shao
    • 2
  • Chin-Yun Lee
    • 2
  • Fu-Yuan Huang
    • 4
  • Li-Min Huang
    • 2
  1. 1.Department of PediatricsBuddhist Tzu Chi General Hospital, Taipei BranchTaipeiTaiwan
  2. 2.Department of PediatricsNational Taiwan University HospitalTaipeiTaiwan
  3. 3.Department of Laboratory MedicineNational Taiwan University HospitalTaipeiTaiwan
  4. 4.Department of PediatricsTaipei Mackay Memorial HospitalTaipeiTaiwan
  5. 5.Department of Human Retrovirology, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands