European Journal of Pediatrics

, Volume 165, Issue 8, pp 540–545

The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis

  • Polyxeni Nicolaidou
  • Ilias Stavrinadis
  • Ioanna Loukou
  • Anna Papadopoulou
  • Helen Georgouli
  • Konstantinos Douros
  • Kostas N. Priftis
  • Dimitrios Gourgiotis
  • Yiannis G. Matsinos
  • Stavros Doudounakis
Original Paper

DOI: 10.1007/s00431-006-0132-1

Cite this article as:
Nicolaidou, P., Stavrinadis, I., Loukou, I. et al. Eur J Pediatr (2006) 165: 540. doi:10.1007/s00431-006-0132-1

Abstract

Introduction

Impaired vitamin K status in cystic fibrosis (CF) has been considered as a newly emerged pathogenetic factor for reduced bone mineral density (BMD).

Objectives

Our aim was to evaluate the effectiveness of vitamin K supplementation in managing bone formation abnormalities in children and adolescents with CF.

Materials and methods

The statuses of vitamins K and D in relation to biochemical markers of bone metabolism and BMD were examined in 20 CF children receiving vitamin D supplements but not vitamin K supplements. Laboratory tests were carried out at the beginning of the study period and after 1 year of vitamin K supplementation (10 mg single oral dose/week) and the results were compared; the results were also compared with those of 25 healthy controls.

Results and discussion

Ten of the CF patients had BMD z-score ≤2.5 (n=5) or between −1 and −2.5 (n=5). Biochemical tests on patients before vitamin K supplementation revealed that the levels of osteoblastic activity markers, namely, bone alkaline phosphatase (BAP), serum osteocalcin (Gla-OC), serum carboxy-terminal propeptide of type I procollagen (PICP) and serum amino-terminal propeptide of type I procollagen (PINP), were significantly reduced compared with those of the controls. These patients had also lower 25-hydroxy-vitamin D (25(OH)D) and vitamin K serum levels, higher undercaboxylated osteocalcin (Glu-OC) and parathormone (PTH) levels and a higher calcium to creatinine ratio (Ca/Cr) than the controls. Vitamin K intake was associated with an increase in Gla-OC, PINP, PICP levels and a decrease in Glu-OC levels. PTH levels were lower after vitamin K supplementation without any difference in BMD z-scores.

Conclusion

Our data indicate that vitamin K supplementation may have a beneficial role in bone health in CF children.

Keywords

Cystic fibrosis Osteopenia Osteoporosis Vitamin D Vitamin K 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Polyxeni Nicolaidou
    • 1
    • 6
  • Ilias Stavrinadis
    • 2
  • Ioanna Loukou
    • 3
  • Anna Papadopoulou
    • 1
  • Helen Georgouli
    • 2
  • Konstantinos Douros
    • 1
  • Kostas N. Priftis
    • 4
  • Dimitrios Gourgiotis
    • 2
  • Yiannis G. Matsinos
    • 5
  • Stavros Doudounakis
    • 3
  1. 1.Third Department of Pediatrics, Athens University Medical SchoolUniversity General Hospital “Attikon”AthensGreece
  2. 2.Second Department of Pediatrics, Athens University Medical School“P. and A. Kyriakou” Children’s HospitalAthensGreece
  3. 3.Cystic Fibrosis Unit“Aghia Sophia” Children’s HospitalAthensGreece
  4. 4.Allergy-Pneumonology DepartmentPenteli Children’s HospitalAthensGreece
  5. 5.Department of Environmental SciencesUniversity of the AegeanMytileneGreece
  6. 6.Third Department of Pediatrics, University of Athens Medical School“Attikon” HospitalChaidariGreece

Personalised recommendations