European Journal of Pediatrics

, Volume 164, Issue 5, pp 271–276

Prevalence of fat redistribution and metabolic disorders in human immunodeficiency virus-infected children

  • Ana María Sánchez Torres
  • Raquel Munoz Muniz
  • Rosario Madero
  • Clementina Borque
  • María Jesús García-Miguel
  • María Isabel De José Gómez
Original Paper

DOI: 10.1007/s00431-004-1610-y

Cite this article as:
Sánchez Torres, A.M., Munoz Muniz, R., Madero, R. et al. Eur J Pediatr (2005) 164: 271. doi:10.1007/s00431-004-1610-y
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Abstract

In this study we assessed the prevalence of fat redistribution and metabolic disorders in a population of HIV-infected children on antiretroviral treatment. To make associations with epidemiological parameters, clinical-immune status, viral load and highly active antiretroviral therapy (HAART), we performed a cross-sectional study in HIV-infected children. Epidemiological parameters (age, sex, family history), clinical and immune status, viral load, and duration of antiretroviral treatment (ART) and HAART, including protease inhibitors, were recorded. Presence of clinical signs of fat redistribution and lipid, glucose and lactic acid levels were evaluated. A total of 56 HIV-infected children, including 30 boys (54%), aged between 21 months and 18 years (mean 9.5 years) were studied. In all, 49 patients (87.5%) were receiving ART (mean duration 4 years) and 43 (77%) were receiving HAART (mean duration 3.6 years). Fat redistribution or lipodystrophy was present in 14 patients (25%); seven had lipohypertrophy (12.5%), two lipoatrophy (3.5%) and five a mixed pattern (8.9%). Fat redistribution was higher in children older than 11 years (50%). Of the lipodystrophic patients, 71.4% presented hypertriglyceridaemia (>130 mg/dl) and 57% hypercholesterolaemia (>180 mg/dl). We found significant associations between lipodystrophy and age, ART and HAART duration and hypertriglyceridaemia ( P <0.001, 0.002, 0.016 and <0.001, respectively), but no significant association with sex, family history, clinical or immune status and viral load. Conclusion:The prevalence of lipodystrophy was 25% (95% confidence interval 14.8–34.6) with lipohypertrophy being the commonest pattern. Clinical fat redistribution was significantly associated with older age, duration of antiretroviral treatment and highly active antiretroviral therapy and hypertriglyceridaemia.

Keywords

Children Highly active antiretroviral treatment HIV infection Hypertriglyceridaemia Lipodystrophy 

Abbreviations

ART

antiretroviral treatment

CDC

Center for Disease Control

HAART

highly active antiretroviral treatment

LPDS

lipodystrophy syndrome

NRTI

nucleoside reverse transcriptase inhibitors

NNRTI

non-nucleoside reverse transcriptase inhibitors

PI

protease inhibitor

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Ana María Sánchez Torres
    • 1
  • Raquel Munoz Muniz
    • 1
  • Rosario Madero
    • 2
  • Clementina Borque
    • 1
  • María Jesús García-Miguel
    • 1
  • María Isabel De José Gómez
    • 1
  1. 1.Department of PaediatricsDivision of Infectious Diseases, La Paz Children’s HospitalMadrid Spain
  2. 2.Department of StatisticsLa Paz Children’s HospitalMadrid Spain

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