European Journal of Pediatrics

, Volume 163, Issue 8, pp 452–456

Management of stage I cervical sarcoma botryoides in childhood and adolescence

  • Susanne E. M. Gruessner
  • Charles O. A. Omwandho
  • Thomas Dreyer
  • Renate Blütters-Sawatzki
  • Alfred Reiter
  • Hans R. Tinneberg
  • Rainer M. Bohle
Original Paper

DOI: 10.1007/s00431-004-1469-y

Cite this article as:
Gruessner, S.E.M., Omwandho, C.O.A., Dreyer, T. et al. Eur J Pediatr (2004) 163: 452. doi:10.1007/s00431-004-1469-y

Abstract

Rhabdomyosarcomas are the most common soft tissue sarcomas in childhood. The botryoid variant arises in infancy from the vagina or urinary bladder and extremely rarely from the uterine cervix. Treatment regimes range from local excision of the tumour to radical hysterectomy with adjuvant multidrug therapy and/or radiotherapy. In cases of minimal cervical invasion, the less invasive local excision in combination with adjuvant chemotherapy has resulted in excellent survival rates with complete functional preservation of the bladder, rectum, vagina, and ovaries. We present here a 30-year literature review and a case report of a cervical sarcoma botryoides in a 5-year-old girl. Conclusion:based on the literature review and our own observation, we recommend minor surgical approaches in combination with chemotherapy as the treatment of choice for early stage I cervical rhabdomyosarcoma.

Keywords

CervixChemotherapyConservative surgeryEmbryonal rhabdomyosarcomaSarcoma botryoides

Abbreviations

IRS

Intergroup Rhabdomyosarcoma Study Group

RMS

rhabdomyosarcoma

VAC

vincristine, adriamycin, cyclophosphamide

VAI

vincristine, adriamycin, ifosfamide

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Susanne E. M. Gruessner
    • 1
  • Charles O. A. Omwandho
    • 2
  • Thomas Dreyer
    • 3
  • Renate Blütters-Sawatzki
    • 4
  • Alfred Reiter
    • 4
  • Hans R. Tinneberg
    • 1
  • Rainer M. Bohle
    • 3
  1. 1.Department of Obstetrics and GynaecologyJustus-Liebig-University GiessenGiessen Germany
  2. 2.Department of BiochemistryUniversity of NairobiNairobi Kenya
  3. 3.Institute of PathologyJustus-Liebig-UniversityGiessen Germany
  4. 4.Department of Paediatric OncologyJustus-Liebig-UniversityGiessen Germany