Medical Microbiology and Immunology

, Volume 185, Issue 4, pp 195–206

Cellular immune reactions directed against Toxoplasma gondii with special emphasis on the central nervous system

  • W. Däubener
  • Ulrich Hadding

DOI: 10.1007/s004300050031

Cite this article as:
Däubener, W. & Hadding, U. Med Microbiol Immunol (1997) 185: 195. doi:10.1007/s004300050031


Toxoplasma gondii is an obligate intracellular parasite which, after primary infection of humans, is maintained in a dormant state by the host cellular immune system. In the event of an acquired immunosuppression, those parasites surviving as dormant cysts in the host may undergo a change in status, proliferate and cause a life-threatening toxoplasmic encephalitis. Over the last decade much knowlege has accumulated concerning the immune response against T. gondii. This review focuses attention particularly on the anti-parasitic effector mechanisms and the cellular immune reactions in the central nervous system during the course of reactivated toxoplasmic encephalitis.

Key words ToxoplasmaIndolamine 23-dioxygenaseNitric oxideT cellCentral nervous systemEncephalitis

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • W. Däubener
    • 1
  • Ulrich Hadding
    • 1
  1. 1.Institut für Med. Mikrobiologie und Virologie, Heinrich-Heine-Universität, Düsseldorf, Postfach 101007, D-40001 Düsseldorf, Germany Tel: 49-211-81-12464; Fax: 49-211-81-15323; e-mail: daeubenemail.rz.uni-duesseldorf.deDE