Cellular immune reactions directed against Toxoplasma gondii with special emphasis on the central nervous system
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- Däubener, W. & Hadding, U. Med Microbiol Immunol (1997) 185: 195. doi:10.1007/s004300050031
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Toxoplasma gondii is an obligate intracellular parasite which, after primary infection of humans, is maintained in a dormant state by the host cellular immune system. In the event of an acquired immunosuppression, those parasites surviving as dormant cysts in the host may undergo a change in status, proliferate and cause a life-threatening toxoplasmic encephalitis. Over the last decade much knowlege has accumulated concerning the immune response against T. gondii. This review focuses attention particularly on the anti-parasitic effector mechanisms and the cellular immune reactions in the central nervous system during the course of reactivated toxoplasmic encephalitis.