Medical Microbiology and Immunology

, Volume 200, Issue 1, pp 39–49

Prevalence and characteristics of hepatitis B and C virus infections in treatment-naïve HIV-infected patients

  • Stefan Reuter
  • Mark Oette
  • Frank Clemens Wilhelm
  • Bastian Beggel
  • Rolf Kaiser
  • Melanie Balduin
  • Finja Schweitzer
  • Jens Verheyen
  • Ortwin Adams
  • Thomas Lengauer
  • Gerd Fätkenheuer
  • Herbert Pfister
  • Dieter Häussinger
Original Investigation

DOI: 10.1007/s00430-010-0172-z

Cite this article as:
Reuter, S., Oette, M., Wilhelm, F.C. et al. Med Microbiol Immunol (2011) 200: 39. doi:10.1007/s00430-010-0172-z

Abstract

In HIV-infected treatment-naïve patients, we analyzed risk factors for either chronic hepatitis B (HBV) infection, occult HBV infection (OHBV) or a positive hepatitis C (HCV) serostatus. A total of 918 patients of the RESINA-cohort in Germany were included in this study. Before initiating antiretroviral therapy, clinical parameters were collected and blood samples were analyzed for antibodies against HIV, HBV and HCV, HBs antigen and viral nucleic acids for HIV and HBV. Present or past HBV infection (i.e. HBsAg and/or anti-HBc) was found in 43.4% of patients. HBsAg was detected in 4.5% (41/918) and HBV DNA in 6.1% (34/554), resulting in OHBV infection in 2.9% (16/554) of patients. OHBV infection could not be ruled out by the presence of anti-HBs (50.1%) or the absence of all HBV seromarkers (25%). A HCV-positive serostatus was associated with the IVDU transmission route, non-African ethnicity, elevated liver parameters (ASL or GGT) and low HIV viral load. Replicative HBV infection and HCV-positive serostatus both correlated with HIV resistance mutations (P = 0.001 and P = 0.028). HBV and HCV infection are frequent co-infections in HIV treatment-naive patients. These co-infections influence viral evolution, clinical parameters and serological markers. Consequently, HIV patients should routinely be tested for HBV and HCV infection before initiating HIV treatment. OHBV infection constituted almost half of all HBV infections with detectable HBV DNA. Due to a lack of risk factors indicating OHBV infection, HBV diagnosis should not only include serological markers but also the detection of HBV DNA.

Keywords

HBVHCVCo-infectionResistance mutationsOccult infection

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Stefan Reuter
    • 1
  • Mark Oette
    • 2
  • Frank Clemens Wilhelm
    • 3
  • Bastian Beggel
    • 4
  • Rolf Kaiser
    • 3
  • Melanie Balduin
    • 3
  • Finja Schweitzer
    • 3
  • Jens Verheyen
    • 3
  • Ortwin Adams
    • 5
  • Thomas Lengauer
    • 4
  • Gerd Fätkenheuer
    • 6
  • Herbert Pfister
    • 3
  • Dieter Häussinger
    • 1
  1. 1.Clinic of Gastroenterology, Hepatology and Infectious DiseasesUniversity HospitalDuesseldorfGermany
  2. 2.Clinic of General Medicine, Gastroenterology and Infectious DiseasesAugustinerinnen HospitalCologneGermany
  3. 3.Institute of VirologyUniversity of CologneCologneGermany
  4. 4.Max Planck Institute for Informatics, Computational Biology and Applied AlgorithmicsSaarbrueckenGermany
  5. 5.Institute of VirologyUniversity Hospital of DüsseldorfDüsseldorfGermany
  6. 6.Department of Internal Medicine IUniversity Hospital of CologneCologneGermany