Medical Microbiology and Immunology

, 198:211

The clinical value of neutrophil extracellular traps

  • Tim Lögters
  • Stefan Margraf
  • Jens Altrichter
  • Jindrich Cinatl
  • Steffen Mitzner
  • Joachim Windolf
  • Martin Scholz
Review

DOI: 10.1007/s00430-009-0121-x

Cite this article as:
Lögters, T., Margraf, S., Altrichter, J. et al. Med Microbiol Immunol (2009) 198: 211. doi:10.1007/s00430-009-0121-x

Abstract

Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.

Keywords

NeutrophilsInnate immunityPathophysiologyNeutrophil extracellular traps

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Tim Lögters
    • 1
  • Stefan Margraf
    • 1
  • Jens Altrichter
    • 1
  • Jindrich Cinatl
    • 2
  • Steffen Mitzner
    • 3
  • Joachim Windolf
    • 1
  • Martin Scholz
    • 1
  1. 1.Department of Trauma and Hand SurgeryHeinrich-Heine UniversityDüsseldorfGermany
  2. 2.Institute for Medical VirologyJohann Wolfgang Goethe UniversityFrankfurt am MainGermany
  3. 3.Division of Nephrology, Department of Internal MedicineUniversity of RostockRostockGermany