Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses
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- Awerkiew, S., Bollschweiler, E., Metzger, R. et al. Med Microbiol Immunol (2003) 192: 137. doi:10.1007/s00430-002-0128-z
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Esophageal squamous cell carcinomas (n=23) and adenocarcinomas (n=14) from German patients were tested for the presence of human papillomavirus (HPV) and Epstein-Barr-Virus (EBV) DNA. No DNA for either genital HPV or epidermodysplasia verruciformis-associated HPV was detected in any tumor. In contrast, 35% of squamous cell carcinomas and 36% of adenocarcinomas were shown to contain EBV DNA by nested polymerase chain reaction.