Anatomy and Embryology

, Volume 197, Issue 3, pp 177–185

Expression of the axon growth-related neural adhesion molecule TAG-1/axonin-1 in the adult mouse brain

  • D. P. Wolfer
  • Roman J. Giger
  • Marijana Stagliar
  • Peter Sonderegger
  • Hans-Peter Lipp
ORIGINAL ARTICLE

DOI: 10.1007/s004290050129

Cite this article as:
Wolfer, D., Giger, R., Stagliar, M. et al. Anat Embryol (1998) 197: 177. doi:10.1007/s004290050129

Abstract

 TAG-1/axonin-1 is a neuronal cell adhesion molecule of the immunoglobulin superfamily. It is predominantly expressed during neural development and has been reported to be involved in axonal growth and pathfinding. Here, the expression of TAG-1/axonin-1 was investigated anatomically in the adult mouse brain by in situ hybridization using digoxigenin-labeled cRNA probes. Low levels of TAG-1/axonin-1 could be detected in cerebellar granule cells, in tufted and mitral cells of the olfactory bulb, and in pyramidal cells of area CA1 and CA3 of the hippocampus. We suspect that the expression of TAG-1/axonin-1 in these structures of the adult brain may serve neural plasticity.

Key words Neural plasticityHippocampusCerebellumOlfactory bulbIn situ hybridization

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • D. P. Wolfer
    • 1
  • Roman J. Giger
    • 2
  • Marijana Stagliar
    • 1
  • Peter Sonderegger
    • 3
  • Hans-Peter Lipp
    • 1
  1. 1.Department of Anatomy University of Zürich, 190 Winterthurerstrasse, CH-8057 Zürich, Switzerland Tel.: (411) 635 5311; Fax: (411) 635 5702; e-mail: dpwolfer@anatomie.unizh.chCH
  2. 2.The Johns Hopkins University, Neuroscience Department, 725 North Wolfe Street, Baltimore, MD 21205, USATP
  3. 3.Department of Biochemistry University of Zürich, 190 Winterthurerstrasse, CH-8057 Zürich, SwitzerlandCH