Brain Structure and Function

, Volume 221, Issue 4, pp 1971–1984

Functional topography of the thalamocortical system in human

  • Rui Yuan
  • Xin Di
  • Paul A. Taylor
  • Suril Gohel
  • Yuan-Hsiung Tsai
  • Bharat B. Biswal
Original Article

DOI: 10.1007/s00429-015-1018-7

Cite this article as:
Yuan, R., Di, X., Taylor, P.A. et al. Brain Struct Funct (2016) 221: 1971. doi:10.1007/s00429-015-1018-7

Abstract

Various studies have indicated that the thalamus is involved in controlling both cortico-cortical information flow and cortical communication with the rest of the brain. Detailed anatomy and functional connectivity patterns of the thalamocortical system are essential to understanding the cortical organization and pathophysiology of a wide range of thalamus-related neurological and neuropsychiatric diseases. The current study used resting-state fMRI to investigate the topography of the human thalamocortical system from a functional perspective. The thalamus-related cortical networks were identified by performing independent component analysis on voxel-based thalamic functional connectivity maps across a large group of subjects. The resulting functional brain networks were very similar to well-established resting-state network maps. Using these brain network components in a spatial regression model with each thalamic voxel’s functional connectivity map, we localized the thalamic subdivisions related to each brain network. For instance, the medial dorsal nucleus was shown to be associated with the default mode, the bilateral executive, the medial visual networks; and the pulvinar nucleus was involved in both the dorsal attention and the visual networks. These results revealed that a single nucleus may have functional connections with multiple cortical regions or even multiple functional networks, and may be potentially related to the function of mediation or modulation of multiple cortical networks. This observed organization of thalamocortical system provided a reference for studying the functions of thalamic sub-regions. The importance of intrinsic connectivity-based mapping of the thalamocortical relationship is discussed, as well as the applicability of the approach for future studies.

Keywords

fMRI Thalamus Resting state 

Supplementary material

429_2015_1018_MOESM1_ESM.docx (3 mb)
Supplementary material 1 (DOCX 3058 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Rui Yuan
    • 1
    • 6
  • Xin Di
    • 1
  • Paul A. Taylor
    • 2
    • 3
  • Suril Gohel
    • 1
  • Yuan-Hsiung Tsai
    • 4
  • Bharat B. Biswal
    • 1
    • 5
  1. 1.Department of Biomedical Engineering, New Jersey Institute of TechnologyUniversity HeightsNewarkUSA
  2. 2.MRC/UCT Medical Imaging Research Unit, Department of Human BiologyUniversity of Cape TownCape TownSouth Africa
  3. 3.African Institute for Mathematical SciencesMuizenbergSouth Africa
  4. 4.Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Chiayi, College of Medicine and School of Medical TechnologyChang-Gung UniversityTaoyuanTaiwan
  5. 5.Department of RadiologyRutgers, The State University of New JerseyNewarkUSA
  6. 6.Department of Electrical Engineering, New Jersey Institute of TechnologyUniversity HeightsNewarkUSA