Brain Structure and Function

, Volume 220, Issue 4, pp 2249–2261

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

  • Yuko Koshimori
  • Barbara Segura
  • Leigh Christopher
  • Nancy Lobaugh
  • Sarah Duff-Canning
  • Romina Mizrahi
  • Clement Hamani
  • Anthony E. Lang
  • Kelly Aminian
  • Sylvain Houle
  • Antonio P. Strafella
Original Article

DOI: 10.1007/s00429-014-0785-x

Cite this article as:
Koshimori, Y., Segura, B., Christopher, L. et al. Brain Struct Funct (2015) 220: 2249. doi:10.1007/s00429-014-0785-x

Abstract

The current study investigates both gray and white matter changes in non-demented Parkinson’s disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre- and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.

Keywords

Parkinson’s disease Cognition Executive dysfunction Cortical thickness White matter Diffusion tensor imaging 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Yuko Koshimori
    • 2
    • 3
  • Barbara Segura
    • 3
    • 5
  • Leigh Christopher
    • 2
    • 3
  • Nancy Lobaugh
    • 3
  • Sarah Duff-Canning
    • 1
    • 6
  • Romina Mizrahi
    • 3
  • Clement Hamani
    • 4
  • Anthony E. Lang
    • 1
  • Kelly Aminian
    • 2
    • 3
  • Sylvain Houle
    • 3
  • Antonio P. Strafella
    • 1
    • 2
    • 3
    • 7
  1. 1.Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease ProgramToronto Western Hospital, UHN, University of TorontoTorontoCanada
  2. 2.Division of Brain, Imaging and Behaviour–Systems NeuroscienceToronto Western Research Institute, UHN, University of TorontoTorontoCanada
  3. 3.Research Imaging CentreCentre for Addiction and Mental Health (CAMH), University of TorontoTorontoCanada
  4. 4.Division of NeurosurgeryToronto Western Hospital, UHN, University of TorontoTorontoCanada
  5. 5.Department of Psychiatry and Clinical Psychobiology, Faculty of MedicineUniversity of BarcelonaBarcelonaSpain
  6. 6.Department of NeuropsychologyToronto Western HospitalTorontoCanada
  7. 7.Toronto Western Hospital and Institute, CAMH-Research Imaging Centre, University of TorontoTorontoCanada

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