Brain Structure and Function

, Volume 219, Issue 1, pp 269–281

Tracing superior longitudinal fasciculus connectivity in the human brain using high resolution diffusion tensor tractography

  • Arash Kamali
  • Adam E. Flanders
  • Joshua Brody
  • Jill V. Hunter
  • Khader M. Hasan
Original Article

DOI: 10.1007/s00429-012-0498-y

Cite this article as:
Kamali, A., Flanders, A.E., Brody, J. et al. Brain Struct Funct (2014) 219: 269. doi:10.1007/s00429-012-0498-y

Abstract

The major language pathways such as superior longitudinal fasciculus (SLF) pathways have been outlined by experimental and diffusion tensor imaging (DTI) studies. The SLF I and some of the superior parietal lobule connections of the SLF pathways have not been depicted by prior DTI studies due to the lack of imaging sensitivity and adequate spatial resolution. In the current study, the trajectory of the SLF fibers has been delineated on five healthy human subjects using diffusion tensor tractography on a 3.0-T scanner at high spatial resolution. We also demonstrate for the first time the trajectory and connectivity of the SLF fibers in relation to other language pathways as well as the superior parietal lobule connections of the language circuit using high spatial resolution DTI in the healthy adult human brain.

Keywords

Diffusion tensor imagingHigh resolutionTractographyAssociation fibersSuperior longitudinal fasciculus

Abbreviations

AF

Arcuate fasciculus

AG

Angular gyrus

BA

Brodmann area

Cing

Cingulum

DTI

Diffusion tensor imaging

DTT

Diffusion tensor tractography

DWI

Diffusion-weighted imaging

EmC

Extreme capsule

FA

Fractional anisotropy

FACT

Fiber assignment by continuous tracking

IFOF

Inferior fronto-occipital fasciculus

ILF

Inferior longitudinal fasciculus

IPL

Inferior parietal lobule

MD

Mean diffusivity

MdLF

Middle longitudinal fasciculus

ROI

Region of interest

SLF

Superior longitudinal fasciculus

SLF TP

Temporoparietal portion of superior longitudinal fasciculus

SMG

Supramarginal gyrus

SPL

Superior parietal lobule

UF

Uncinate fasciculus

WM

White matter

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Arash Kamali
    • 1
  • Adam E. Flanders
    • 2
  • Joshua Brody
    • 1
  • Jill V. Hunter
    • 3
  • Khader M. Hasan
    • 4
  1. 1.Department of RadiologyCooper University Hospital, UMDNJCamdenUSA
  2. 2.Department of RadiologyThomas Jefferson University HospitalPhiladelphiaUSA
  3. 3.Department of NeuroradiologyTexas Childrens HospitalHoustonUSA
  4. 4.Department of Diagnostic and Interventional ImagingUniversity of Texas Health Science Center Houston-Medical SchoolHoustonUSA