Brain Structure and Function

, Volume 213, Issue 6, pp 571–585

Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity


  • Nan-kuei Chen
    • Brain Imaging and Analysis CenterDuke University Medical Center
  • Ying-hui Chou
    • Department of Occupational TherapyFu Jen Catholic University
  • Allen W. Song
    • Brain Imaging and Analysis CenterDuke University Medical Center
    • Brain Imaging and Analysis CenterDuke University Medical Center
    • Center for the Study of Aging and Human DevelopmentDuke University Medical Center
Original Article

DOI: 10.1007/s00429-009-0218-4

Cite this article as:
Chen, N., Chou, Y., Song, A.W. et al. Brain Struct Funct (2009) 213: 571. doi:10.1007/s00429-009-0218-4


Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify behaviorally relevant, intrinsic FC networks. Nineteen younger adults (20–28 years) and 19 healthy, older adults (63–78 years) were assessed with fMRI and diffusion tensor imaging (DTI). Results indicated that FC involving a distributed network of brain regions, particularly the inferior frontal gyri, exhibited age-related change in the correlation with perceptual-motor speed (choice reaction time; RT). No relation between FC and RT was evident for younger adults, whereas older adults exhibited a significant age-related slowing of perceptual-motor speed, which was mediated by decreasing FC. Older adults’ FC values were in turn associated positively with white matter integrity (from DTI) within the genu of the corpus callosum. The developed FC analysis illustrates the value of identifying connectivity by combining structural, functional, and behavioral data.


AgingBrain imagingFunctional connectivityCognitionWhite matter integrityReaction time

Copyright information

© Springer-Verlag 2009