Anatomy and Embryology

, Volume 209, Issue 5, pp 349–355

Wnts and the neural crest


DOI: 10.1007/s00429-005-0459-9

Cite this article as:
Schmidt, C. & Patel, K. Anat Embryol (2005) 209: 349. doi:10.1007/s00429-005-0459-9


The neural crest is a multipotent tissue that originates between the neural epithelium and non-neural ectoderm, which can develop into numerous cell types, including neurons, glia, pigment cells, smooth muscle, cartilage and bone. Work in a variety of animal models has shown that a number of signalling factors are necessary for the induction, delamination and differentiation of neural crest cells. However one family of proteins, the Wnts, shows an overriding influence on this tissue. Here we review recent studies that pinpoint specific roles that Wnts play in the development of the neural crest.


WntsNeural crestInductionDelaminationDifferentiation

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of Veterinary Basic SciencesThe Royal Veterinary CollegeLondonUK
  2. 2.Institute of AnatomyLudwigs-Maximillians-University of MunichMunichGermany