Anatomy and Embryology

, Volume 210, Issue 5, pp 519–523

Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia

Authors

    • Department of PsychiatryUniversity of Bonn
    • Brain Imaging Center West, Institute of MedicineResearch Center Jülich
  • Christian Boy
    • Brain Imaging Center West, Institute of MedicineResearch Center Jülich
  • Philipp T. Meyer
    • Brain Imaging Center West, Institute of MedicineResearch Center Jülich
  • Harald Scherk
    • Department of PsychiatryUniversity of Bonn
    • Department of PsychiatrySaarland University Hospital
  • Michael Wagner
    • Department of PsychiatryUniversity of Bonn
  • Hans Herzog
    • Brain Imaging Center West, Institute of MedicineResearch Center Jülich
  • Heinz H. Coenen
    • Institute of Nuclear ChemistryResearch Center Jülich
  • Kai Vogeley
    • Department of PsychiatryUniversity of Bonn
    • Brain Imaging Center West, Institute of MedicineResearch Center Jülich
  • Peter Falkai
    • Department of PsychiatryUniversity of Bonn
    • Department of PsychiatrySaarland University Hospital
  • Karl Zilles
    • Brain Imaging Center West, Institute of MedicineResearch Center Jülich
    • C. & O. Vogt Institute for Brain ResearchUniversity of Duesseldorf
  • Wolfgang Maier
    • Department of PsychiatryUniversity of Bonn
  • Andreas Bauer
    • Brain Imaging Center West, Institute of MedicineResearch Center Jülich
Original Article

DOI: 10.1007/s00429-005-0036-2

Cite this article as:
Hurlemann, R., Boy, C., Meyer, P.T. et al. Anat Embryol (2005) 210: 519. doi:10.1007/s00429-005-0036-2

Abstract

The brain serotonin-2A receptor (5-HT2AR) has been implicated in both the pathology of schizophrenia and the therapeutic action of atypical antipsychotics. However, little is known about the 5-HT2AR status before the onset of schizophrenia and before the exposure to antipsychotics. We used [18F] altanserin and positron emission tomography (PET) in a pilot study of 6 individuals suspected to be at elevated risk for schizophrenia and seven age-matched controls to test the hypothesis that regional 5-HT2AR binding is altered in the prodromal stages of schizophrenia. Distribution volume ratios (DVRs) as a proxy for 5-HT2AR availability were significantly reduced in prefrontal cortex regions of at-risk subjects, implicating early abnormalities of serotonergic neurotransmission that antecede the onset of schizophrenia.

Keywords

Serotonin-2A[(18)F]AltanserinPETAt-riskPsychosisSchizophrenia

Abbreviations

DVR

distribution volume ratio

ROI

region of interest

at-risk

subjects with prodromal states for schizophrenia

Copyright information

© Springer-Verlag 2005