Virchows Archiv

, Volume 440, Issue 4, pp 404–409

Calponin and h-caldesmon expression in atypical fibroxanthoma and superficial leiomyosarcoma

  • A. Sakamoto
  • Y. Oda
  • H. Yamamoto
  • Y. Oshiro
  • K. Miyajima
  • E. Itakura
  • S. Tamiya
  • Y. Honda
  • A. Ishihara
  • Y. Iwamoto
  • M Tsuneyoshi
Original Article

DOI: 10.1007/s004280100521

Cite this article as:
Sakamoto, A., Oda, Y., Yamamoto, H. et al. Virchows Arch (2002) 440: 404. doi:10.1007/s004280100521

Abstract

To evaluate smooth muscle differentiation, myogenic markers [desmin, alpha-smooth muscle actin (SMA), and muscle-specific actin (HHF35)] have been widely used. Calponin and h-caldesmon, which are cytoskeleton-associated actin-binding proteins, have been reported to be more specific myogenic markers, especially since myofibroblasts express a small amount of h-caldesmon. Atypical fibroxanthoma (AFX) occurs in the sun-exposed skin of the elderly and follows a benign clinical course. Histologically, AFX, which is a pleomorphic spindle cell tumor and considered to be a superficial variant of malignant fibrous histiocytoma, also mimics leiomyosarcoma. AFX has been thought to differentiate along pathways with fibrohistiocytic and myofibroblastic phenotypes. AFX (n=10), superficial leiomyosarcoma (S-LMS) (n=17) and benign fibrous histiocytoma (BFH) (n=17) were analyzed for myofibroblastic and smooth muscle differentiation immunohistochemically from the viewpoint of comparison. AFX and BFH showed immunoreactivities respectively for calponin (3/10, 11/17), desmin (3/10, 1/17), SMA (3/10, 13/17), and HHF35 (1/10, 5/17), but failed to express h-caldesmon (0/10, 0/17). S-LMS had a high immunoreactive rate of calponin (17/17), desmin (13/17), SMA (16/17), and HHF35 (16/17), while also expressing caldesmon (11/17). The results reveal that AFX and BFH have immunoreactivities for several myogenic markers, with myofibroblastic differentiation (calponin: ±, h-caldesmon: —), but without the smooth muscle differentiation seen in S-LMS (calponin:+, h-caldesmon: ±). In addition, calponin and h-caldesmon are considered to be useful markers for distinguishing AFX from S-LMS.

Atypical fibroxanthoma Superficial leiomyosarcoma Benign fibrous histiocytoma Calponin H-caldesmon 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • A. Sakamoto
    • 1
  • Y. Oda
    • 1
  • H. Yamamoto
    • 1
  • Y. Oshiro
    • 3
  • K. Miyajima
    • 1
  • E. Itakura
    • 1
  • S. Tamiya
    • 1
  • Y. Honda
    • 4
  • A. Ishihara
    • 5
  • Y. Iwamoto
    • 2
  • M Tsuneyoshi
    • 1
  1. 1.Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582Japan
  2. 2.Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, FukuokaJapan
  3. 3.Department of Pathology, Matsuyama Red Cross Hospital, MatsuyamaJapan
  4. 4.First Department of Pathology, Faculty of Medicine, Kumamoto University, KumamotoJapan
  5. 5.Department of Pathology, Nobeoka Hospital, Miyazaki, JapanJapan

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