Virchows Archiv

, Volume 432, Issue 4, pp 371–375

Gastrin stimulates epithelial cell proliferation in the oesophagus of rats

  • Yves Van Nieuwenhove
  • Toon De Backer
  • Duan Chen
  • Rolf Håkanson
  • G. Willems
ORIGINAL ARTICLE

DOI: 10.1007/s004280050180

Cite this article as:
Van Nieuwenhove, Y., De Backer, T., Chen, D. et al. Virchows Archiv (1998) 432: 371. doi:10.1007/s004280050180

Abstract

 Gastrin can induce mitotic stimulation in the oxyntic mucosa of the stomach, sometimes leading to abnormal growth. We examined whether gastrin was able to influence cell proliferation in the oesophageal epithelium. Rats were treated with gastrin, omeprazole or saline for 3 days, or were subjected to fundectomy or sham operation. Bromodeoxyuridine labelling (LI) and mitotic (MI) indices were counted in the proliferative zone of the squamous epithelium. Infusion of exogenous gastrin, treatment with omeprazole or fundectomy raised the LI and the MI values in the oesophageal epithelium, indicating that gastrin stimulates cell proliferation in the oesophageal mucosa in the rat.

Key words GastrinOesophagusCell kineticsRats

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Yves Van Nieuwenhove
    • 1
  • Toon De Backer
    • 1
  • Duan Chen
    • 2
  • Rolf Håkanson
    • 2
  • G. Willems
    • 1
  1. 1.Department of Experimental Surgery, Free University of Brussels, Laarbeeklaan 101, B-1090 Brussels, Belgium Tel.: (+32)-2/477 65 37, Fax (+32)-2/477 65 05 e-mail: yvnieuwe@heel.vub.ac.beBE
  2. 2.Department of Pharmacology, University of Lund, Lund, SwedenSE