Virchows Archiv

, Volume 432, Issue 1, pp 49–52

High incidence of upper gastrointestinal tract involvement in Crohn’s disease

  • G. Oberhuber
  • Michael Hirsch
  • Manfred Stolte
ORIGINAL ARTICLE

DOI: 10.1007/s004280050133

Cite this article as:
Oberhuber, G., Hirsch, M. & Stolte, M. Virchows Archiv (1998) 432: 49. doi:10.1007/s004280050133

Abstract

 A better definition of gastric mucosal histology in Crohn’s disease permits a more accurate estimation of the frequency of upper gastrointestinal tract involvement in Crohn’s disease. In a retrospective study of 792 patients with known Crohn’s disease the incidence of lesions associated with the disease was determined in the duodenum, duodenal bulb, and gastric antrum and body mucosa. Crohn’s disease was identified histologically in the antrum in 41.5%, in the body in 37.1%, in the duodenum in 12.1%, and in the duodenal bulb in 13%. In a further 15% and 17.4% of cases, Crohn’s disease of the duodenum and duodenal bulb, respectively, was suspected. The positive predictive value of focal gastritis in patients undergoing upper endoscopy and not yet known to have Crohn’s disease is as high as 94%. Thus, a high proportion of Crohn’s disease patients show upper gastrointestinal tract involvement, with the major involvement in the antrum. Focal gastritis suggesting Crohn’s disease turned out to have a high positive predictive value in patients not known to have Crohn’s disease at the time of gastroscopy.

Key words StomachDuodenumCrohn’s diseaseFocal gastritis

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • G. Oberhuber
    • 1
  • Michael Hirsch
    • 2
  • Manfred Stolte
    • 2
  1. 1.Department of Clinical Pathology, University of Vienna, Medical School, Währinger Gürtel 18–20, A-1090 Vienna, Austria Tel.: (++43) 1 40400 3650, Fax: (++43) 1 4053402 e-mail: Georg.Oberhuber@akh-wien.ac.atAT
  2. 2.Institute of Pathology, Bayreuth, GermanyDE