Virchows Archiv

, Volume 430, Issue 6, pp 461–466

Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma

An immunohistochemical study
  • N.-H. Chow
  • Hsiao-Sheng Liu
  • Hsiao-Bai Yang
  • Shih-Huang Chan
  • Ih-Jen Su
ORIGINAL ARTICLE

DOI: 10.1007/s004280050056

Cite this article as:
Chow, N., Liu, H., Yang, H. et al. Virchows Archiv (1997) 430: 461. doi:10.1007/s004280050056

Abstract

 The class I tyrosine kinase growth-factor receptors include epidermal growth factor receptor (EGFR), ErbB2 (c-erbB-2, HER-2/neu), ErbB3 and ErbB4. To elucidate their role in the regulation of homeostasis and carcinogenesis, we examined the expression of the receptors in normal urothelium and in urothelial carcinoma by immunohistochemistry. EGFR was expressed in the basal cells of normal urothelium, while ErbB2, ErbB3 and ErbB4 were present mainly in the superficial layer. A distinct reciprocal distribution was observed between the EGFR and the remaining members of the subclass (P = 0.0001). Both BCL-2 protein and Ki-67 antigen (MIB-1) showed a strong positive association with EGFR (P = 0.002) and an inverse correlation with ErbB2, ErbB3 or ErbB4 (P = 0.0004, 0.0000, and 0.001, respectively). With regard to carcinoma, there was no important relationship between receptor overexpression and tumour grading (P > 0.1), while only EGFR overexpression was correlated with muscular invasion (P = 0.02). Coexpression of EGFR-ErbB3 and ErbB3-ErbB4 was more often detected in high-grade tumours and correlated with the extent of tumour invasion. Our data indicate that class I receptors are differentially expressed in normal urothelium in vivo, but an orchestrated expression pattern does not exist during tumorigenesis.

Key words erbB Receptor familyUrotheliumDifferentiationCarcinogenesis

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • N.-H. Chow
    • 1
  • Hsiao-Sheng Liu
    • 2
  • Hsiao-Bai Yang
    • 1
  • Shih-Huang Chan
    • 3
  • Ih-Jen Su
    • 1
  1. 1.Department of Pathology, National Cheng Kung University Hospital, 138, Sheng-Li Road, Tainan, Taiwan 70428, Republic of China Fax: (886) 6-2766195, E-mail: chownh@mail.ncku.edu.twTW
  2. 2.Department of Microbiology, National Cheng Kung University, Tainan, Taiwan 704, Republic of ChinaTW
  3. 3.Department of Statistics, National Cheng Kung University, Tainan, Taiwan 704, Republic of ChinaTW