Virchows Archiv

, Volume 439, Issue 2, pp 185–190

Serial extracellular matrix changes in neointimal lesions of human coronary artery after percutaneous transluminal coronary angioplasty: clinical significance of early tenascin-C expression

  • Kyoko Imanaka-Yoshida
  • Ritsuko Matsuura
  • Naoki Isaka
  • Takeshi Nakano
  • Teruyo Sakakura
  • Toshimichi Yoshida
Original Article

DOI: 10.1007/s004280000390

Cite this article as:
Imanaka-Yoshida, K., Matsuura, R., Isaka, N. et al. Virchows Arch (2001) 439: 185. doi:10.1007/s004280000390

Abstract.

It has become clear that deposition of extracellular matrix(ECM) proteins is a major cause of human restenosis after percutaneous coronary angioplasty(PTCA). To define the composition and organization of the involved ECM in human restenotic tissue, we morphologically and semiquantitatively analyzed specimens obtained by means of directional coronary atherectomy at various stages after PTCA with anti-fibronectin, tenascin-C, collagens I and III, and PG-M/versican antibodies. Tenascin-C deposition transiently increased within 1 month after PTCA, when smooth muscle cell migration and proliferation was active. Following the disappearance of tenascin-C, PG-M/versican accumulation increased and peaked between 1 month and 3 months when clinical restenosis was most actively progressing. At later stages, the PG-M/versican was replaced by a more mature ECM consisting of collagens I and III. The volume ratio of elastin remained at a low level throughout. Our results demonstrate that the matrix proteins of human restenotic lesions sequentially change after angioplasty and that tenascin-C could be a key molecule in the early stages.

Angioplasty Restenosis Extracellular matrix Tenascin Proteoglycan 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Kyoko Imanaka-Yoshida
    • 1
  • Ritsuko Matsuura
    • 2
  • Naoki Isaka
    • 2
  • Takeshi Nakano
    • 2
  • Teruyo Sakakura
    • 1
  • Toshimichi Yoshida
    • 1
  1. 1.The Department of Pathology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507Japan
  2. 2.The Division of Cardiology of the First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514-8507Japan