Virchows Archiv

, Volume 436, Issue 6, pp 617–621

Respiratory syncytial virus-induced chronic bronchiolitis in experimentally infected calves

  • S. Philippou
  • P. Otto
  • P. Reinhold
  • M. Elschner
  • H.-J. Streckert
Original Article

DOI: 10.1007/s004280000197

Cite this article as:
Philippou, S., Otto, P., Reinhold, P. et al. Virchows Archiv (2000) 436: 617. doi:10.1007/s004280000197

Abstract 

Human (RSV) and bovine (BRSV) respiratory syncytial virus cause similar infections of the lower respiratory tract. Therefore, experimentally infected calves are suited to the study of RSV-induced chronic bronchiolitis. Colostrum-fed calves aged 17–24 days were successfully infected with BRSV. BRSV strain 375 was applied as an aerosol on 4 consecutive days. Clinical symptoms were already evident on the 1st day after infection. The calves were necropsied 12 weeks after the first infection. Focal severe chronic bronchiolitis with atelectasis and focal bronchiolitis obliterans were demonstrated. The bronchiolar lumina were filled with secretion. Transmission electron microscopy revealed an alteration of the ciliogenesis and partial loss of cilia. Immunhistochemically virus P protein could still be detected, mainly in the epithelial cells of the inflamed bronchioli.

Key words Respiratory syncytial virus RSV Chronic bronchiolitis RSV persistence 

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • S. Philippou
    • 1
  • P. Otto
    • 3
  • P. Reinhold
    • 3
  • M. Elschner
    • 3
  • H.-J. Streckert
    • 2
  1. 1.Institute of Pathology, Augusta Hospital, Zeppelinstrasse 18, 44791 Bochum, Germany Fax: +49-234-9585604DE
  2. 2.Dr. Streckert-Diagnostica, Witten, GermanyDE
  3. 3.Federal Institute for Health Protection of Costumers and Veterinary Medicine, Jena Branch, GermanyDE

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