Virchows Archiv

, Volume 465, Issue 1, pp 1–14

Molecular classification of breast cancer

  • Darina Vuong
  • Peter T. Simpson
  • Benjamin Green
  • Margaret C. Cummings
  • Sunil R. Lakhani
Review and Perspectives

DOI: 10.1007/s00428-014-1593-7

Cite this article as:
Vuong, D., Simpson, P.T., Green, B. et al. Virchows Arch (2014) 465: 1. doi:10.1007/s00428-014-1593-7

Abstract

Breast cancer is a complex, multifaceted disease encompassing a great variety of entities that show considerable variation in clinical, morphological and molecular attributes. Traditional classifications including histological assessment and clinical staging are used to guide patient management. In recent years, there has been exponential progress in molecular analysis with profound implications for our understanding of breast cancer biology and, hence, classification. There are now genome-based frameworks for the molecular categorisation of breast cancer including the development of prognostic and predictive signatures that potentially allow individualisation of treatment. Here we review the current state of the molecular classifications of in situ and invasive breast cancer including special subtypes. Future perspectives are also provided.

Keywords

Breast cancer molecular pathologyBiomarkersGenomicsClassification

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Darina Vuong
    • 1
    • 2
  • Peter T. Simpson
    • 1
  • Benjamin Green
    • 1
    • 3
  • Margaret C. Cummings
    • 1
    • 2
    • 4
  • Sunil R. Lakhani
    • 1
    • 2
    • 4
  1. 1.The University of QueenslandUQ Centre for Clinical ResearchBrisbaneAustralia
  2. 2.Pathology QueenslandThe Royal Brisbane and Women’s HospitalBrisbaneAustralia
  3. 3.Department of SurgeryThe Royal Brisbane and Women’s HospitalBrisbaneAustralia
  4. 4.The University of QueenslandSchool of MedicineBrisbaneAustralia