Virchows Archiv

, Volume 464, Issue 1, pp 79–83

HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women


    • Šikl’s Department of Pathology, University Hospital, Faculty of MedicineCharles University
    • Bioptická laboratoř s.r.o.
  • Jana Kašpírková
    • Department of GeneticsBioptická laboratoř s.r.o.
  • Ondřej Májek
    • Institute of Biostatistics and AnalysesMasaryk University
  • Iva Kinkorová
    • Bioptická laboratoř s.r.o.
Original Article

DOI: 10.1007/s00428-013-1511-4

Cite this article as:
Ondič, O., Kašpírková, J., Májek, O. et al. Virchows Arch (2014) 464: 79. doi:10.1007/s00428-013-1511-4


HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.


CervixDysplasiaCIN IIIHPVVaccination

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© Springer-Verlag Berlin Heidelberg 2013