Original Article

Virchows Archiv

, Volume 464, Issue 1, pp 79-83

First online:

HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women

  • Ondrej OndičAffiliated withŠikl’s Department of Pathology, University Hospital, Faculty of Medicine, Charles UniversityBioptická laboratoř s.r.o. Email author 
  • , Jana KašpírkováAffiliated withDepartment of Genetics, Bioptická laboratoř s.r.o.
  • , Ondřej MájekAffiliated withInstitute of Biostatistics and Analyses, Masaryk University
  • , Iva KinkorováAffiliated withBioptická laboratoř s.r.o.

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HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.


Cervix Dysplasia CIN III HPV Vaccination