Virchows Archiv

, Volume 464, Issue 1, pp 79–83

HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women

  • Ondrej Ondič
  • Jana Kašpírková
  • Ondřej Májek
  • Iva Kinkorová
Original Article

DOI: 10.1007/s00428-013-1511-4

Cite this article as:
Ondič, O., Kašpírková, J., Májek, O. et al. Virchows Arch (2014) 464: 79. doi:10.1007/s00428-013-1511-4
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Abstract

HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.

Keywords

CervixDysplasiaCIN IIIHPVVaccination

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Ondrej Ondič
    • 1
    • 2
  • Jana Kašpírková
    • 3
  • Ondřej Májek
    • 4
  • Iva Kinkorová
    • 2
  1. 1.Šikl’s Department of Pathology, University Hospital, Faculty of MedicineCharles UniversityPilsenCzech Republic
  2. 2.Bioptická laboratoř s.r.o.PilsenCzech Republic
  3. 3.Department of GeneticsBioptická laboratoř s.r.o.PilsenCzech Republic
  4. 4.Institute of Biostatistics and AnalysesMasaryk UniversityBrnoCzech Republic