Virchows Archiv

, Volume 458, Issue 1, pp 109–113

Paratesticular fibrous pseudotumor—an IgG4-related disorder?

  • Hans Bösmüller
  • Claus Hann von Weyhern
  • Patrick Adam
  • Vedat Alibegovic
  • Gregor Mikuz
  • Falko Fend
Original Article

DOI: 10.1007/s00428-010-0995-4

Cite this article as:
Bösmüller, H., von Weyhern, C.H., Adam, P. et al. Virchows Arch (2011) 458: 109. doi:10.1007/s00428-010-0995-4

Abstract

Paratesticular fibrous pseudotumor (nodular periorchitis, inflammatory pseudotumor of the spermatic cord) is a rare, benign condition of unknown etiology characterized by solitary or multiple intrascrotal nodules composed of dense fibrous tissue with a variable, sometimes sparse inflammatory infiltrate. Based on certain similarities to other fibroinflammatory disorders characterized by infiltrates of IgG4-expressing plasma cells and recently subsumed under the heading of IgG4-mediated diseases, we investigated the plasma cell distribution and immunoglobulin isotypes in three cases of paratesticular fibrous and inflammatory pseudotumor. All three cases showed a high number of IgG4-positive plasma cells with an IgG4 to IgG ratio of 44–48%. This finding indicates that paratesticular fibrous pseudotumor might belong to the growing list of IgG4-related diseases, which by now includes such diverse entities as retroperitoneal fibrosis, sclerosing pancreatitis and cholangitis, Riedel’s thyroiditis, or sclerosing sialadenitis.

Keywords

Inflammatory pseudotumorParatesticular fibrous pseudotumorTestisIgG4

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Hans Bösmüller
    • 1
  • Claus Hann von Weyhern
    • 2
  • Patrick Adam
    • 2
  • Vedat Alibegovic
    • 1
  • Gregor Mikuz
    • 3
  • Falko Fend
    • 2
  1. 1.Department of PathologyKrankenhaus Barmherzige SchwesternLinzAustria
  2. 2.Department of PathologyUniversity of TübingenTübingenGermany
  3. 3.Department of PathologyUniversity of InnsbruckInnsbruckAustria