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Paratesticular fibrous pseudotumor—an IgG4-related disorder?

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Abstract

Paratesticular fibrous pseudotumor (nodular periorchitis, inflammatory pseudotumor of the spermatic cord) is a rare, benign condition of unknown etiology characterized by solitary or multiple intrascrotal nodules composed of dense fibrous tissue with a variable, sometimes sparse inflammatory infiltrate. Based on certain similarities to other fibroinflammatory disorders characterized by infiltrates of IgG4-expressing plasma cells and recently subsumed under the heading of IgG4-mediated diseases, we investigated the plasma cell distribution and immunoglobulin isotypes in three cases of paratesticular fibrous and inflammatory pseudotumor. All three cases showed a high number of IgG4-positive plasma cells with an IgG4 to IgG ratio of 44–48%. This finding indicates that paratesticular fibrous pseudotumor might belong to the growing list of IgG4-related diseases, which by now includes such diverse entities as retroperitoneal fibrosis, sclerosing pancreatitis and cholangitis, Riedel’s thyroiditis, or sclerosing sialadenitis.

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Krankenhaus Barmherzige Schwestern, Seilerstätte 4, 4020, Linz, Austria

    Hans Bösmüller & Vedat Alibegovic

  2. Department of Pathology, University of Tübingen, Tübingen, Germany

    Claus Hann von Weyhern, Patrick Adam & Falko Fend

  3. Department of Pathology, University of Innsbruck, Innsbruck, Austria

    Gregor Mikuz

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  1. Hans Bösmüller
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  2. Claus Hann von Weyhern
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  3. Patrick Adam
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  4. Vedat Alibegovic
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  5. Gregor Mikuz
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  6. Falko Fend
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Correspondence to Hans Bösmüller.

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Bösmüller, H., von Weyhern, C.H., Adam, P. et al. Paratesticular fibrous pseudotumor—an IgG4-related disorder?. Virchows Arch 458, 109–113 (2011). https://doi.org/10.1007/s00428-010-0995-4

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  • DOI: https://doi.org/10.1007/s00428-010-0995-4

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