Virchows Archiv

, Volume 458, Issue 1, pp 109–113

Paratesticular fibrous pseudotumor—an IgG4-related disorder?

  • Hans Bösmüller
  • Claus Hann von Weyhern
  • Patrick Adam
  • Vedat Alibegovic
  • Gregor Mikuz
  • Falko Fend
Original Article

DOI: 10.1007/s00428-010-0995-4

Cite this article as:
Bösmüller, H., von Weyhern, C.H., Adam, P. et al. Virchows Arch (2011) 458: 109. doi:10.1007/s00428-010-0995-4

Abstract

Paratesticular fibrous pseudotumor (nodular periorchitis, inflammatory pseudotumor of the spermatic cord) is a rare, benign condition of unknown etiology characterized by solitary or multiple intrascrotal nodules composed of dense fibrous tissue with a variable, sometimes sparse inflammatory infiltrate. Based on certain similarities to other fibroinflammatory disorders characterized by infiltrates of IgG4-expressing plasma cells and recently subsumed under the heading of IgG4-mediated diseases, we investigated the plasma cell distribution and immunoglobulin isotypes in three cases of paratesticular fibrous and inflammatory pseudotumor. All three cases showed a high number of IgG4-positive plasma cells with an IgG4 to IgG ratio of 44–48%. This finding indicates that paratesticular fibrous pseudotumor might belong to the growing list of IgG4-related diseases, which by now includes such diverse entities as retroperitoneal fibrosis, sclerosing pancreatitis and cholangitis, Riedel’s thyroiditis, or sclerosing sialadenitis.

Keywords

Inflammatory pseudotumor Paratesticular fibrous pseudotumor Testis IgG4 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Hans Bösmüller
    • 1
  • Claus Hann von Weyhern
    • 2
  • Patrick Adam
    • 2
  • Vedat Alibegovic
    • 1
  • Gregor Mikuz
    • 3
  • Falko Fend
    • 2
  1. 1.Department of PathologyKrankenhaus Barmherzige SchwesternLinzAustria
  2. 2.Department of PathologyUniversity of TübingenTübingenGermany
  3. 3.Department of PathologyUniversity of InnsbruckInnsbruckAustria

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