Virchows Archiv

, Volume 456, Issue 2, pp 141–151

Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers

  • Andrew H. Beck
  • Robert B. West
  • Matt van de Rijn
Review and Perspective

DOI: 10.1007/s00428-009-0774-2

Cite this article as:
Beck, A.H., West, R.B. & van de Rijn, M. Virchows Arch (2010) 456: 141. doi:10.1007/s00428-009-0774-2

Abstract

Soft tissue sarcomas are malignant neoplasms derived from mesenchymal tissues. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. In the past decade, gene expression profiling has been applied to sarcomas to facilitate understanding of sarcoma pathogenesis and to identify diagnostic, prognostic, and predictive markers. In this paper, we review this body of work and discuss how gene expression profiling has led to advancements in the understanding of sarcoma pathobiology, the identification of clinically useful biomarkers, and the refinement of sarcoma classification schemes. Lastly, we conclude with a discussion of strategies to further optimize the translation of gene expression data into a greater understanding of sarcoma pathogenesis and improved clinical outcomes for sarcoma patients.

Keywords

Gene expression profilingMicroarraysGenomicsBioinformaticsTumor biologySoft tissue tumorsSarcomasBiomarkersMolecular pathologySurgical pathology

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Andrew H. Beck
    • 1
  • Robert B. West
    • 1
    • 2
  • Matt van de Rijn
    • 1
  1. 1.Pathology DepartmentStanford University Medical CenterStanfordUSA
  2. 2.Pathology and Laboratory ServicePalo Alto Veterans Affairs Health Care SystemPalo AltoUSA