Virchows Archiv

, 454:133

The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia

Authors

    • Department of PathologyOspedale di Circolo
  • Francesca Franzi
    • Anatomic Pathology Unit, Department of Human MorphologyUniversity of Insubria
  • Silvia Marchet
    • Anatomic Pathology Unit, Department of Human MorphologyUniversity of Insubria
  • Giovanna Finzi
    • Department of PathologyOspedale di Circolo
  • Moira Clerici
    • Department of Biomedical, Experimental and Clinical SciencesUniversity of Insubria
  • Davide Vigetti
    • Department of Biomedical, Experimental and Clinical SciencesUniversity of Insubria
  • Anna Maria Chiaravalli
    • Department of PathologyOspedale di Circolo
  • Fausto Sessa
    • Anatomic Pathology Unit, Department of Human MorphologyUniversity of Insubria
    • Department of PathologyFondazione IRCCS Multimedica
  • Carlo Capella
    • Anatomic Pathology Unit, Department of Human MorphologyUniversity of Insubria
Original Article

DOI: 10.1007/s00428-008-0710-x

Cite this article as:
La Rosa, S., Franzi, F., Marchet, S. et al. Virchows Arch (2009) 454: 133. doi:10.1007/s00428-008-0710-x

Abstract

Acinar cell carcinoma (ACC) is a rare pancreatic cancer which may be difficult to distinguish from other solid nonadenocarcinoma tumors. The diagnosis depends on the demonstration of acinar differentiation, obtained with antibodies recognizing various pancreatic enzymes that, although specific, show different sensitivity. The C-terminal portion of the BCL10 protein shows homology with carboxyl ester hydrolase (CEH), an enzyme produced by pancreatic acinar cells. We investigated the usefulness of a C-terminal BCL10 monoclonal antibody in the diagnosis of ACCs. We examined normal pancreases and different pancreatic tumors including ACCs, mixed acinar–endocrine carcinomas, ductal adenocarcinomas, mucinous, serous, solid pseudopapillary, and endocrine neoplasms. In addition, various normal tissues and cases of pancreatic metaplasia of the gastroesophageal mucosa, cases of ectopic pancreas, gastrointestinal endocrine tumors, salivary and breast acinic cell carcinomas, gastric adenocarcinomas with and without acinar differentiation, and hepatocellular carcinomas were studied. BCL10 immunoreactivity paralleled that of CEH and was restricted to acinar cells of normal and ectopic pancreas, of pancreatic metaplasia, and of ACCs. The anti-BCL10 antibody was more sensitive in detecting ACCs and pancreatic metaplasia than antibodies directed against other pancreatic enzymes. We suggest using BCL10 antibody for diagnosing pancreatic tumors and whenever an acinar differentiation is suspected in gastrointestinal neoplastic and metaplastic lesions.

Keywords

PancreasBCL10Acinar cellAcinar cell carcinoma

Copyright information

© Springer-Verlag 2008