Virchows Archiv

, Volume 453, Issue 3, pp 243–248

AMACR expression in colorectal cancer is associated with left-sided tumor localization

  • Andreas Marx
  • Philipp Simon
  • Ronald Simon
  • Martina Mirlacher
  • Jakob R. Izbicki
  • Emre Yekebas
  • Jussuf T. Kaifi
  • Luigi Terracciano
  • Guido Sauter
Original Article

DOI: 10.1007/s00428-008-0646-1

Cite this article as:
Marx, A., Simon, P., Simon, R. et al. Virchows Arch (2008) 453: 243. doi:10.1007/s00428-008-0646-1

Abstract

Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the β-oxidation of branched-chain fatty acids and fatty acid derivatives. Altered expression levels of AMACR have been described in various cancers including colorectal cancer (CRC). To determine the potential prognostic impact of AMACR expression, we analyzed 1,315 CRC on a tissue microarray (TMA) by immunohistochemistry (IHC). Clinical follow-up data were available from all cancer patients. Positive AMACR staining was observed in 1,074 (81.7%) of the 1,315 cases including 276 cancers with weak (21.0%) and 798 cancers with strong staining (60.7%). AMACR IHC was significantly associated with tumor grade, stage, non-mucinous phenotype, and left-sided tumor localization (p < 0.0001 each). AMACR positivity was observed in 65.8% of cancers from the right-sided colon, in 73.2% of cancers from the colon transversum, in 81.1% of cancers from the colon descendens, and in 88.9% of the distal left-sided cancers (sigma and rectum; p < 0.0001). However, AMACR staining results were unrelated to clinical outcome. It is concluded that AMACR cannot serve as a prognostic marker in CRC. We hypothesize that the association of AMACR expression with tumor localization may be related to differences in the metabolism/exposure to fatty acids occurring along the colon.

Keywords

AMACRColorectal cancer

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Andreas Marx
    • 1
  • Philipp Simon
    • 1
  • Ronald Simon
    • 1
  • Martina Mirlacher
    • 1
  • Jakob R. Izbicki
    • 2
  • Emre Yekebas
    • 2
  • Jussuf T. Kaifi
    • 2
  • Luigi Terracciano
    • 3
  • Guido Sauter
    • 1
  1. 1.Institute for PathologyUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.Department of SurgeryUniversity Medical Center Hamburg-EppendorfHamburgGermany
  3. 3.Institute of PathologyUniversity Hospital BaselBaselSwitzerland