Virchows Archiv

, Volume 453, Issue 2, pp 171–176

Lymph node pathology in pulmonary veno-occlusive disease and pulmonary capillary heamangiomatosis

Authors

    • Department of PathologyMarie Lannelongue Surgical Centre
    • Service d’anatomie pathologiqueCentre chirurgical Marie Lannelongue
  • Élisabeth Dulmet
    • Department of PathologyMarie Lannelongue Surgical Centre
  • Élie Fadel
    • Department of Thoracic and Vascular Surgery and Heart-Lung TransplantationMarie Lannelongue Surgical Centre
  • Philippe Dartevelle
    • Department of Thoracic and Vascular Surgery and Heart-Lung TransplantationMarie Lannelongue Surgical Centre
Original Article

DOI: 10.1007/s00428-008-0636-3

Cite this article as:
Thomas de Montpréville, V., Dulmet, É., Fadel, É. et al. Virchows Arch (2008) 453: 171. doi:10.1007/s00428-008-0636-3

Abstract

To assess the histological bases of lymphadenomegaly, which has been reported as a frequent radiological finding in pulmonary veno-occlusive disease (PVOD), we have reviewed pulmonary and mediastinal lymph nodes resected during lung transplantations in 19 patients suffering from PVOD and related pulmonary capillary haemangiomatosis (PCH). Lymphatic congestion was common and was often obvious in subsegmental and segmental lymph nodes. Vascular transformation of the sinuses, intra-sinusal haemorrhage with erythrophagocytosis and lymphoid follicular hyperplasia were frequent especially in lobar, hilar and mediastinal lymph nodes. These lesions were very significantly less frequent in 33 cases of pulmonary hypertension unrelated to PVOD. Due to their thoracic location, these non-specific lesions could simulate other diagnoses such as Castleman disease or lymphangioleiomyomatosis. However, in the setting of pulmonary hypertension, they should suggest PVOD and PCH. They are probably secondary to venous congestion, veno-lymphatic shunts and angiogenetic factors associated with these diseases.

Keywords

Pulmonary veno-occlusive diseasePulmonary capillary haemangiomatosisLymph nodesVascular transformation of sinusesErythrophagocytosis

Copyright information

© Springer-Verlag 2008